p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression levels were found to be positively correlated with the severity of human IVDD. In a mouse tail suspension (TS)-ind...

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Bibliographic Details
Main Authors: Hui Che, Jie Li, You Li, Cheng Ma, Huan Liu, Jingyi Qin, Jianghui Dong, Zhen Zhang, Cory J Xian, Dengshun Miao, Liping Wang, Yongxin Ren
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
intervertebral disc degeneration
cell cycle
cell proliferation
oxidative stress
p16
Online Access:https://elifesciences.org/articles/52570

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