The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery disease
Abstract Background The level of lipoprotein-associated phospholipase A2 (LP-PLA2) in serum is independently correlated to coronary artery diseases (CAD). The aim of the study was to determine whether LP-PLA2 activity is positively associated with the seriousness of CAD. Methods Amount to 1056 patie...
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doaj-793687c56372483c8450ca24117fd1182020-11-25T03:23:27ZengBMCBMC Cardiovascular Disorders1471-22612020-06-012011610.1186/s12872-020-01580-4The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery diseaseHao Zhang0Yang Gao1Dan Wu2Dingguo Zhang3Department of Cardiology, The Affiliated Hospital of Yangzhou UniversityDepartment of Cardiology, The Affiliated Hospital of Yangzhou UniversityDepartment of Cardiology, The Affiliated Hospital of Yangzhou UniversityDepartment of Cardiology, First Affiliated Hospital of Nanjing Medical UniversityAbstract Background The level of lipoprotein-associated phospholipase A2 (LP-PLA2) in serum is independently correlated to coronary artery diseases (CAD). The aim of the study was to determine whether LP-PLA2 activity is positively associated with the seriousness of CAD. Methods Amount to 1056 patients suspected of having CAD underwent coronary angiography (CAG) to determine the seriousness of CAD. According to the amount of diseased coronary branches, the 1056 patients were split into three groups: single-vessel stenosis group, multiple-vessels stenosis group (> or = 2 diseased coronary branches),and control group (no diseased coronary branches). According to CAG results, electrocardiography, cardiac biomarker, and clinical presentation, all patients were split into four groups: acute myocardial infarction (AMI), unstable angina (UA), stable angina (SA), and control groups (excluding CAD). The activity of LP-PLA2 was compared statistically among the subgroups. Receiver operating characteristic analysis was applied to investigate the role of LP-PLA2 in evaluating the presence and seriousness of CAD. Results The level of LP-PLA2 increased in line with the number of diseased coronary branches. The levels of LP-PLA2 in the AMI and UA groups were observably higher when compared with the control and SA groups. LP-PLA2 had 75.6% sensitivity and 67.3% specificity for recognizing CAD, and 53.0% sensitivity and 80.3% specificity for recognizing severe coronary artery lesions. Conclusion The activity of LP-PLA2 is positively correlated to the seriousness of CAD.http://link.springer.com/article/10.1186/s12872-020-01580-4Lipoprotein-associated phospholipase A2Cardiovascular diseaseCoronary artery diseasesCoronary angiography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hao Zhang Yang Gao Dan Wu Dingguo Zhang |
spellingShingle |
Hao Zhang Yang Gao Dan Wu Dingguo Zhang The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery disease BMC Cardiovascular Disorders Lipoprotein-associated phospholipase A2 Cardiovascular disease Coronary artery diseases Coronary angiography |
author_facet |
Hao Zhang Yang Gao Dan Wu Dingguo Zhang |
author_sort |
Hao Zhang |
title |
The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery disease |
title_short |
The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery disease |
title_full |
The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery disease |
title_fullStr |
The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery disease |
title_full_unstemmed |
The relationship of lipoprotein-associated phospholipase A2 activity with the seriousness of coronary artery disease |
title_sort |
relationship of lipoprotein-associated phospholipase a2 activity with the seriousness of coronary artery disease |
publisher |
BMC |
series |
BMC Cardiovascular Disorders |
issn |
1471-2261 |
publishDate |
2020-06-01 |
description |
Abstract Background The level of lipoprotein-associated phospholipase A2 (LP-PLA2) in serum is independently correlated to coronary artery diseases (CAD). The aim of the study was to determine whether LP-PLA2 activity is positively associated with the seriousness of CAD. Methods Amount to 1056 patients suspected of having CAD underwent coronary angiography (CAG) to determine the seriousness of CAD. According to the amount of diseased coronary branches, the 1056 patients were split into three groups: single-vessel stenosis group, multiple-vessels stenosis group (> or = 2 diseased coronary branches),and control group (no diseased coronary branches). According to CAG results, electrocardiography, cardiac biomarker, and clinical presentation, all patients were split into four groups: acute myocardial infarction (AMI), unstable angina (UA), stable angina (SA), and control groups (excluding CAD). The activity of LP-PLA2 was compared statistically among the subgroups. Receiver operating characteristic analysis was applied to investigate the role of LP-PLA2 in evaluating the presence and seriousness of CAD. Results The level of LP-PLA2 increased in line with the number of diseased coronary branches. The levels of LP-PLA2 in the AMI and UA groups were observably higher when compared with the control and SA groups. LP-PLA2 had 75.6% sensitivity and 67.3% specificity for recognizing CAD, and 53.0% sensitivity and 80.3% specificity for recognizing severe coronary artery lesions. Conclusion The activity of LP-PLA2 is positively correlated to the seriousness of CAD. |
topic |
Lipoprotein-associated phospholipase A2 Cardiovascular disease Coronary artery diseases Coronary angiography |
url |
http://link.springer.com/article/10.1186/s12872-020-01580-4 |
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