ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIA
Background : We evaluated albumin cobalt binding (ACB) assay as a prognostic marker for severe malaria in a medical college setting . Methods :Consecutive adult patients admitted with both vivax and falciparum malaria were evaluated with ACB assay at the time of admission. Detailed work up and in...
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doaj-79494cbfa0e44bf3816c479eafec03092020-11-24T22:54:12ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062017-06-0191e2017041e201704110.4084/mjhid.2017.0411692ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIAKinjalka Ghosh0M G Muddeshwar1Monoj Lokhande2Kanjaksha Ghosh3Seth Gs Medical college & KEM HospitalGovernment Medical college & Hospitals , NagpurIndira Gandhi Medical college Hospital, NagpurSurat Rakta Dan Kendra & research CentreBackground : We evaluated albumin cobalt binding (ACB) assay as a prognostic marker for severe malaria in a medical college setting . Methods :Consecutive adult patients admitted with both vivax and falciparum malaria were evaluated with ACB assay at the time of admission. Detailed work up and individual patient directed management were instituted in addition to immediate artemisin based antimalarial therapy. Results :100 consecutive patient ( 50 with vivax and 50 with falciparum malaria ) were evaluated . Reference range for ACB assay was established using 50 adult healthy ( 25 male and 25 female ) individuals . 16 out of 50 p. falciparum infected developed complicated malaria. All malaria infected patients had high ACB levels ( P<0.0001). There was step wise increase in ACB levels from healthy volunteers to different category of malaria( P<0.0001 ) without any overlap. Conclusion: ACB can be used as a robust simple and cheap prognostic marker for organ dysfunction in severe malaria.http://www.mjhid.org/index.php/mjhid/article/view/2949Malaria , Complicated malaria, Cobalt albumin binding assay, Vivax malaria , Falciparum malaria. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kinjalka Ghosh M G Muddeshwar Monoj Lokhande Kanjaksha Ghosh |
spellingShingle |
Kinjalka Ghosh M G Muddeshwar Monoj Lokhande Kanjaksha Ghosh ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIA Mediterranean Journal of Hematology and Infectious Diseases Malaria , Complicated malaria, Cobalt albumin binding assay, Vivax malaria , Falciparum malaria. |
author_facet |
Kinjalka Ghosh M G Muddeshwar Monoj Lokhande Kanjaksha Ghosh |
author_sort |
Kinjalka Ghosh |
title |
ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIA |
title_short |
ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIA |
title_full |
ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIA |
title_fullStr |
ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIA |
title_full_unstemmed |
ALBUMIN COBALT BINDING OR ISCHAEMIA MODIFIED ALBUMIN: A TEST OF GREAT PROGNOSTIC VALUE IN MALARIA |
title_sort |
albumin cobalt binding or ischaemia modified albumin: a test of great prognostic value in malaria |
publisher |
PAGEPress Publications |
series |
Mediterranean Journal of Hematology and Infectious Diseases |
issn |
2035-3006 |
publishDate |
2017-06-01 |
description |
Background : We evaluated albumin cobalt binding (ACB) assay as a prognostic marker for severe malaria in a medical college setting .
Methods :Consecutive adult patients admitted with both vivax and falciparum malaria were evaluated with ACB assay at the time of admission. Detailed work up and individual patient directed management were instituted in addition to immediate artemisin based antimalarial therapy.
Results :100 consecutive patient ( 50 with vivax and 50 with falciparum malaria ) were evaluated . Reference range for ACB assay was established using 50 adult healthy ( 25 male and 25 female ) individuals . 16 out of 50 p. falciparum infected developed complicated malaria. All malaria infected patients had high ACB levels ( P<0.0001). There was step wise increase in ACB levels from healthy volunteers to different category of malaria( P<0.0001 ) without any overlap.
Conclusion: ACB can be used as a robust simple and cheap prognostic marker for organ dysfunction in severe malaria. |
topic |
Malaria , Complicated malaria, Cobalt albumin binding assay, Vivax malaria , Falciparum malaria. |
url |
http://www.mjhid.org/index.php/mjhid/article/view/2949 |
work_keys_str_mv |
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