S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1β or Lipocalin-2
A pleiotropic signaling lipid, sphingosine-1-phosphate (S1P), has been implicated in various pathophysiological processes supporting tumor growth and metastasis. However, there are only a few descriptive studies suggesting a role of S1P in tumor lymphangiogenesis, which is critical for tumor growth...
Main Authors: | Shahzad N. Syed, Michaela Jung, Andreas Weigert, Bernhard Brüne |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2017-01-01
|
Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2017/7510496 |
Similar Items
-
Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation
by: Shahzad Nawaz Syed, et al.
Published: (2019-07-01) -
Iron Handling in Tumor-Associated Macrophages—Is There a New Role for Lipocalin-2?
by: Michaela Jung, et al.
Published: (2017-09-01) -
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment
by: Christina Mertens, et al.
Published: (2018-03-01) -
Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin
by: Christina Mertens, et al.
Published: (2021-03-01) -
Macrophage Polarization In The Tumor Microenvironment
by: Bernhard Brüne, et al.
Published: (2015-08-01)