MicroRNA Involvement in Osteosarcoma
Osteosarcoma (OS) is the most common primary malignant bone tumor, usually arising in the long bones of adolescents and young adults. While our knowledge of the molecular pathogenesis of OS has increased in recent years, we are still far from a comprehensive understanding of the molecular mechanisms...
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2012-01-01
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Series: | Sarcoma |
Online Access: | http://dx.doi.org/10.1155/2012/359739 |
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doaj-795e795ddde246a490ecdc1f1ee7784c2020-11-25T00:07:13ZengHindawi LimitedSarcoma1357-714X1369-16432012-01-01201210.1155/2012/359739359739MicroRNA Involvement in OsteosarcomaEisuke Kobayashi0Francis J. Hornicek1Zhenfeng Duan2Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USAOsteosarcoma (OS) is the most common primary malignant bone tumor, usually arising in the long bones of adolescents and young adults. While our knowledge of the molecular pathogenesis of OS has increased in recent years, we are still far from a comprehensive understanding of the molecular mechanisms of the disease, such as its tumorigenesis, specific mediators of disease progression, occurrence of chemoresistance, and development of metastasis. After the recent discovery of microRNAs (miRNAs), their critical roles in molecular biological processes have been of great interest in the cancer research field, including research on sarcomas. MiRNAs are highly conserved noncoding RNAs which play important roles as oncogenic or suppressive genes to simultaneously regulate multiple targets. Recent genome-wide screening using miRNA expression profiles has identified specific miRNA expression patterns that are associated with the biological and clinical properties of cancers. Additionally, miRNAs and their target genes or proteins can be potential novel biomarkers or therapeutic targets for cancer. However, there are several challenges that must be addressed in order to translate miRNA-based therapeutics to the clinical setting. In this review, we summarize the current understanding of the roles that miRNAs play in OS, and highlight their potential as biomarkers or therapeutic targets.http://dx.doi.org/10.1155/2012/359739 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eisuke Kobayashi Francis J. Hornicek Zhenfeng Duan |
spellingShingle |
Eisuke Kobayashi Francis J. Hornicek Zhenfeng Duan MicroRNA Involvement in Osteosarcoma Sarcoma |
author_facet |
Eisuke Kobayashi Francis J. Hornicek Zhenfeng Duan |
author_sort |
Eisuke Kobayashi |
title |
MicroRNA Involvement in Osteosarcoma |
title_short |
MicroRNA Involvement in Osteosarcoma |
title_full |
MicroRNA Involvement in Osteosarcoma |
title_fullStr |
MicroRNA Involvement in Osteosarcoma |
title_full_unstemmed |
MicroRNA Involvement in Osteosarcoma |
title_sort |
microrna involvement in osteosarcoma |
publisher |
Hindawi Limited |
series |
Sarcoma |
issn |
1357-714X 1369-1643 |
publishDate |
2012-01-01 |
description |
Osteosarcoma (OS) is the most common primary malignant bone tumor, usually arising in the long bones of adolescents and young adults. While our knowledge of the molecular pathogenesis of OS has increased in recent years, we are still far from a comprehensive understanding of the molecular mechanisms of the disease, such as its tumorigenesis, specific mediators of disease progression, occurrence of chemoresistance, and development of metastasis. After the recent discovery of microRNAs (miRNAs), their critical roles in molecular biological processes have been of great interest in the cancer research field, including research on sarcomas. MiRNAs are highly conserved noncoding RNAs which play important roles as oncogenic or suppressive genes to simultaneously regulate multiple targets. Recent genome-wide screening using miRNA expression profiles has identified specific miRNA expression patterns that are associated with the biological and clinical properties of cancers. Additionally, miRNAs and their target genes or proteins can be potential novel biomarkers or therapeutic targets for cancer. However, there are several challenges that must be addressed in order to translate miRNA-based therapeutics to the clinical setting. In this review, we summarize the current understanding of the roles that miRNAs play in OS, and highlight their potential as biomarkers or therapeutic targets. |
url |
http://dx.doi.org/10.1155/2012/359739 |
work_keys_str_mv |
AT eisukekobayashi micrornainvolvementinosteosarcoma AT francisjhornicek micrornainvolvementinosteosarcoma AT zhenfengduan micrornainvolvementinosteosarcoma |
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