Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain.
Reciprocal inhibition between inhibitory projection neurons has been proposed as the most efficient circuit motif to achieve the flexible selection of one stimulus among competing alternatives. However, whether such a motif exists in networks that mediate selection is unclear. Here, we study the con...
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doaj-7963e7dbed0a4551892fc2a32e8646352020-11-25T00:08:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8586510.1371/journal.pone.0085865Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain.C Alex GoddardShreesh P MysoreAstra S BryantJohn R HuguenardEric I KnudsenReciprocal inhibition between inhibitory projection neurons has been proposed as the most efficient circuit motif to achieve the flexible selection of one stimulus among competing alternatives. However, whether such a motif exists in networks that mediate selection is unclear. Here, we study the connectivity within the nucleus isthmi pars magnocellularis (Imc), a GABAergic nucleus that mediates competitive selection in the midbrain stimulus selection network. Using laser photostimulation of caged glutamate, we find that feedback inhibitory connectivity is global within the Imc. Unlike typical lateral inhibition in other circuits, intra-Imc inhibition remains functionally powerful over long distances. Anatomically, we observed long-range axonal projections and retrograde somatic labeling from focal injections of bi-directional tracers in the Imc, consistent with spatial reciprocity of intra-Imc inhibition. Together, the data indicate that spatially reciprocal inhibition of inhibition occurs throughout the Imc. Thus, the midbrain selection circuit possesses the most efficient circuit motif possible for fast, reliable, and flexible selection.http://europepmc.org/articles/PMC3897538?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
C Alex Goddard Shreesh P Mysore Astra S Bryant John R Huguenard Eric I Knudsen |
spellingShingle |
C Alex Goddard Shreesh P Mysore Astra S Bryant John R Huguenard Eric I Knudsen Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain. PLoS ONE |
author_facet |
C Alex Goddard Shreesh P Mysore Astra S Bryant John R Huguenard Eric I Knudsen |
author_sort |
C Alex Goddard |
title |
Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain. |
title_short |
Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain. |
title_full |
Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain. |
title_fullStr |
Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain. |
title_full_unstemmed |
Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain. |
title_sort |
spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Reciprocal inhibition between inhibitory projection neurons has been proposed as the most efficient circuit motif to achieve the flexible selection of one stimulus among competing alternatives. However, whether such a motif exists in networks that mediate selection is unclear. Here, we study the connectivity within the nucleus isthmi pars magnocellularis (Imc), a GABAergic nucleus that mediates competitive selection in the midbrain stimulus selection network. Using laser photostimulation of caged glutamate, we find that feedback inhibitory connectivity is global within the Imc. Unlike typical lateral inhibition in other circuits, intra-Imc inhibition remains functionally powerful over long distances. Anatomically, we observed long-range axonal projections and retrograde somatic labeling from focal injections of bi-directional tracers in the Imc, consistent with spatial reciprocity of intra-Imc inhibition. Together, the data indicate that spatially reciprocal inhibition of inhibition occurs throughout the Imc. Thus, the midbrain selection circuit possesses the most efficient circuit motif possible for fast, reliable, and flexible selection. |
url |
http://europepmc.org/articles/PMC3897538?pdf=render |
work_keys_str_mv |
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