Selective Expression of Calcium-Binding Protein S100A7 in Lung Cancer
Background and objective S100A7 is a member of S100 family and its overexpression has been previously associated with carcinogenesis of certain cancers. The aim of this study is to explore the expression of calcium-binding protein S100A7 in lung cancer. Methods In the present study, RT-PCR, Western-...
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2009-01-01
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Online Access: | http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2009.01.009&path%5B%5D=210 |
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doaj-79643fee52d5461ab5e303aad03e538c2020-11-24T22:15:22ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872009-01-011215458Selective Expression of Calcium-Binding Protein S100A7 in Lung CancerHao ZHANGDanhui LIUSuozhu SUNJifu LIUShanshan WUYing MAOMingying LISheng FENGYanguang XIAODacheng HEXueyuan XIAOBackground and objective S100A7 is a member of S100 family and its overexpression has been previously associated with carcinogenesis of certain cancers. The aim of this study is to explore the expression of calcium-binding protein S100A7 in lung cancer. Methods In the present study, RT-PCR, Western-blot and immunohistochemistry were used to analyze the different expression of S100A7 in lung cancer tissues and paired noncancerous lung tissues. Results The specific expression of S100A7 was found in squamous cell carcinomas and large cell lung carcinomas, whereas it was not detected in adenocarcinomas, small cell carcinomas, other cell types of lung cancer and normal lung tissues as well as paired noncancerous lung tissues. Conclusion S100A7 was selectively expressed in squamous cell carcinomas and large cell lung carcinomas and may serve as a potential marker for lung cancer diagnosis.http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2009.01.009&path%5B%5D=210Lung neoplasmsHuman S100A7 proteinBiological tumor markersPathology |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
Hao ZHANG Danhui LIU Suozhu SUN Jifu LIU Shanshan WU Ying MAO Mingying LI Sheng FENG Yanguang XIAO Dacheng HE Xueyuan XIAO |
spellingShingle |
Hao ZHANG Danhui LIU Suozhu SUN Jifu LIU Shanshan WU Ying MAO Mingying LI Sheng FENG Yanguang XIAO Dacheng HE Xueyuan XIAO Selective Expression of Calcium-Binding Protein S100A7 in Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms Human S100A7 protein Biological tumor markers Pathology |
author_facet |
Hao ZHANG Danhui LIU Suozhu SUN Jifu LIU Shanshan WU Ying MAO Mingying LI Sheng FENG Yanguang XIAO Dacheng HE Xueyuan XIAO |
author_sort |
Hao ZHANG |
title |
Selective Expression of Calcium-Binding Protein S100A7 in Lung Cancer |
title_short |
Selective Expression of Calcium-Binding Protein S100A7 in Lung Cancer |
title_full |
Selective Expression of Calcium-Binding Protein S100A7 in Lung Cancer |
title_fullStr |
Selective Expression of Calcium-Binding Protein S100A7 in Lung Cancer |
title_full_unstemmed |
Selective Expression of Calcium-Binding Protein S100A7 in Lung Cancer |
title_sort |
selective expression of calcium-binding protein s100a7 in lung cancer |
publisher |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
series |
Chinese Journal of Lung Cancer |
issn |
1009-3419 1999-6187 |
publishDate |
2009-01-01 |
description |
Background and objective S100A7 is a member of S100 family and its overexpression has been previously associated with carcinogenesis of certain cancers. The aim of this study is to explore the expression of calcium-binding protein S100A7 in lung cancer. Methods In the present study, RT-PCR, Western-blot and immunohistochemistry were used to analyze the different expression of S100A7 in lung cancer tissues and paired noncancerous lung tissues. Results The specific expression of S100A7 was found in squamous cell carcinomas and large cell lung carcinomas, whereas it was not detected in adenocarcinomas, small cell carcinomas, other cell types of lung cancer and normal lung tissues as well as paired noncancerous lung tissues. Conclusion S100A7 was selectively expressed in squamous cell carcinomas and large cell lung carcinomas and may serve as a potential marker for lung cancer diagnosis. |
topic |
Lung neoplasms Human S100A7 protein Biological tumor markers Pathology |
url |
http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2009.01.009&path%5B%5D=210 |
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1725794669461241856 |