The emerging role of epigenetics in human autoimmune disorders
Abstract Epigenetic pathways play a pivotal role in the development and function of the immune system. Over the last decade, a growing body of studies has been published out seeking to explain a correlation between epigenetic modifications and the development of autoimmune disorders. Epigenetic chan...
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doaj-796fdc3c0e56493099b3451fb73228422020-11-24T20:47:25ZengBMCClinical Epigenetics1868-70751868-70832019-02-0111111510.1186/s13148-019-0632-2The emerging role of epigenetics in human autoimmune disordersRoberta Mazzone0Clemens Zwergel1Marco Artico2Samanta Taurone3Massimo Ralli4Antonio Greco5Antonello Mai6Department of Chemistry and Technologies of Drugs, Sapienza University of RomeDepartment of Chemistry and Technologies of Drugs, Sapienza University of RomeDepartment of Sense Organs, Sapienza University of RomeIRCCS G.B. Bietti FoundationDepartment of Sense Organs, Sapienza University of RomeDepartment of Sense Organs, Sapienza University of RomeDepartment of Chemistry and Technologies of Drugs, Sapienza University of RomeAbstract Epigenetic pathways play a pivotal role in the development and function of the immune system. Over the last decade, a growing body of studies has been published out seeking to explain a correlation between epigenetic modifications and the development of autoimmune disorders. Epigenetic changes, such as DNA methylation, histone modifications, and noncoding RNAs, are involved in the pathogenesis of autoimmune diseases mainly by regulating gene expression. This paper reviews the importance of epigenetic alterations during the development of the most prevalent human autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), Sjogren’s syndrome (SS), autoimmune thyroid diseases (AITD), and type 1 diabetes (T1D), aiming to provide new insights in the pathogenesis of autoimmune diseases and the possibility to develop novel therapeutic approaches targeting the epigenome.http://link.springer.com/article/10.1186/s13148-019-0632-2EpigeneticsGene expressionAutoimmune diseasesEpigenetic pathways |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roberta Mazzone Clemens Zwergel Marco Artico Samanta Taurone Massimo Ralli Antonio Greco Antonello Mai |
spellingShingle |
Roberta Mazzone Clemens Zwergel Marco Artico Samanta Taurone Massimo Ralli Antonio Greco Antonello Mai The emerging role of epigenetics in human autoimmune disorders Clinical Epigenetics Epigenetics Gene expression Autoimmune diseases Epigenetic pathways |
author_facet |
Roberta Mazzone Clemens Zwergel Marco Artico Samanta Taurone Massimo Ralli Antonio Greco Antonello Mai |
author_sort |
Roberta Mazzone |
title |
The emerging role of epigenetics in human autoimmune disorders |
title_short |
The emerging role of epigenetics in human autoimmune disorders |
title_full |
The emerging role of epigenetics in human autoimmune disorders |
title_fullStr |
The emerging role of epigenetics in human autoimmune disorders |
title_full_unstemmed |
The emerging role of epigenetics in human autoimmune disorders |
title_sort |
emerging role of epigenetics in human autoimmune disorders |
publisher |
BMC |
series |
Clinical Epigenetics |
issn |
1868-7075 1868-7083 |
publishDate |
2019-02-01 |
description |
Abstract Epigenetic pathways play a pivotal role in the development and function of the immune system. Over the last decade, a growing body of studies has been published out seeking to explain a correlation between epigenetic modifications and the development of autoimmune disorders. Epigenetic changes, such as DNA methylation, histone modifications, and noncoding RNAs, are involved in the pathogenesis of autoimmune diseases mainly by regulating gene expression. This paper reviews the importance of epigenetic alterations during the development of the most prevalent human autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), Sjogren’s syndrome (SS), autoimmune thyroid diseases (AITD), and type 1 diabetes (T1D), aiming to provide new insights in the pathogenesis of autoimmune diseases and the possibility to develop novel therapeutic approaches targeting the epigenome. |
topic |
Epigenetics Gene expression Autoimmune diseases Epigenetic pathways |
url |
http://link.springer.com/article/10.1186/s13148-019-0632-2 |
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