Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China
Abstract Importance Neuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma. Objective To systematically summarize the clinical characteristics of children with neuroblastom...
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Wiley
2020-09-01
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Series: | Pediatric Investigation |
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Online Access: | https://doi.org/10.1002/ped4.12214 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni |
spellingShingle |
Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China Pediatric Investigation Neuroblastoma Pediatric Multidisciplinary care Prognosis |
author_facet |
Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni |
author_sort |
Yan Su |
title |
Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_short |
Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_full |
Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_fullStr |
Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_full_unstemmed |
Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China |
title_sort |
treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in china |
publisher |
Wiley |
series |
Pediatric Investigation |
issn |
2574-2272 |
publishDate |
2020-09-01 |
description |
Abstract Importance Neuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma. Objective To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center. Methods This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed, treated, and followed‐up in the Hematology‐Oncology Center of Beijing Children’s Hospital from 2007 to 2019. Results The median age at diagnosis was 34 months; 80.8% of the patients were younger than 5 years of age. Notably, 243 patients (23.3%) were classified as low‐risk, 249 patients (23.9%) were classified as intermediate‐risk, and 549 (52.7%) were classified as high‐risk. Furthermore, 956 patients underwent surgical resections; 986 (94.7%) patients received chemotherapy; and 176 patients with high‐risk neuroblastoma received hematopoietic stem cell transplantation. The 5‐year event‐free survival (EFS) rate was 91.3% and 5‐year overall survival (OS) rate was 97.5% in low‐risk group; in the intermediate‐risk group, these rates were 85.1% and 96.7%, respectively, while they were 37.7% and 48.9% in the high‐risk group (P < 0.001 for both). The 5‐year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014 (P < 0.001). In total, 278 patients (26.7%) exhibited tumor relapse or progression; the median interval until relapse or progression was 14 months. Of the 233 patients who died, 83% died of relapse or progression of neuroblastoma and 4.3% died of therapy‐related complications. Interpretation The 5‐year OS rate was low in high‐risk patients, compared with low‐and intermediate‐risk patients. Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma. Additional treatment strategies should be sought to improve the prognosis of patients with high‐risk neuroblastoma. |
topic |
Neuroblastoma Pediatric Multidisciplinary care Prognosis |
url |
https://doi.org/10.1002/ped4.12214 |
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doaj-79945da7ed8c49bcba5a4a6dc0203a7c2021-05-02T22:01:07ZengWileyPediatric Investigation2574-22722020-09-014315716710.1002/ped4.12214Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in ChinaYan Su0Hong Qin1Chenghao Chen2Shengcai Wang3Shihan Zhang4Dawei Zhang5Mei Jin6Yun Peng7Lejian He8Xiaoman Wang9Suyun Qian10Maoquan Qin11Ming Ge12Fuquan Zhang13Qi Zeng14Huanmin Wang15Xiaoli Ma16Xin Ni17Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education Key Laboratory of Major Diseases in Children Hematology Oncology Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Surgical Oncology Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Thoracic Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otorhinolaryngology Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaBeijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education Key Laboratory of Major Diseases in Children Hematology Oncology Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaBeijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education Key Laboratory of Major Diseases in Children Hematology Oncology Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaBeijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education Key Laboratory of Major Diseases in Children Hematology Oncology Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaImaging Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Pathology Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Ultrasound Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaPediatric Intensive Care Unit Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaBeijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education Key Laboratory of Major Diseases in Children Hematology Oncology Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Neurosurgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Radiation Oncology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Surgical Oncology Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaBeijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education Key Laboratory of Major Diseases in Children Hematology Oncology Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaDepartment of Otorhinolaryngology Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing ChinaAbstract Importance Neuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma. Objective To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center. Methods This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed, treated, and followed‐up in the Hematology‐Oncology Center of Beijing Children’s Hospital from 2007 to 2019. Results The median age at diagnosis was 34 months; 80.8% of the patients were younger than 5 years of age. Notably, 243 patients (23.3%) were classified as low‐risk, 249 patients (23.9%) were classified as intermediate‐risk, and 549 (52.7%) were classified as high‐risk. Furthermore, 956 patients underwent surgical resections; 986 (94.7%) patients received chemotherapy; and 176 patients with high‐risk neuroblastoma received hematopoietic stem cell transplantation. The 5‐year event‐free survival (EFS) rate was 91.3% and 5‐year overall survival (OS) rate was 97.5% in low‐risk group; in the intermediate‐risk group, these rates were 85.1% and 96.7%, respectively, while they were 37.7% and 48.9% in the high‐risk group (P < 0.001 for both). The 5‐year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014 (P < 0.001). In total, 278 patients (26.7%) exhibited tumor relapse or progression; the median interval until relapse or progression was 14 months. Of the 233 patients who died, 83% died of relapse or progression of neuroblastoma and 4.3% died of therapy‐related complications. Interpretation The 5‐year OS rate was low in high‐risk patients, compared with low‐and intermediate‐risk patients. Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma. Additional treatment strategies should be sought to improve the prognosis of patients with high‐risk neuroblastoma.https://doi.org/10.1002/ped4.12214NeuroblastomaPediatricMultidisciplinary carePrognosis |