Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis
ObjectiveTo investigate the levels of molecular markers of prethrombotic state in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) and their significance. MethodsSeventy-two LC patients who were admitted to our hospital from 2011 to 2013 were selected for analysis. Among the patients,...
Main Author: | |
---|---|
Format: | Article |
Language: | zho |
Published: |
Editorial Department of Journal of Clinical Hepatology
2015-03-01
|
Series: | Linchuang Gandanbing Zazhi |
Subjects: | |
Online Access: | http://www.lcgdbzz.org/qk_content.asp?id=6375&ClassID=212131156 |
Summary: | ObjectiveTo investigate the levels of molecular markers of prethrombotic state in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) and their significance. MethodsSeventy-two LC patients who were admitted to our hospital from 2011 to 2013 were selected for analysis. Among the patients, thirty-two were diagnosed with PVT by computed tomography. The plasma levels of granular membrane protein-140 (GMP-140), von Willebrand Factor antigen (vWF:Ag), thrombomodulin (TM), and D-dimer (DD) were measured by enzyme-linked immunosorbent assay. The data were analyzed using SPSS 11.0. Continuous data were expressed as mean ± standard deviation and compared between the two groups by independent-samples t test. ResultsThe concentrations of GMP-140, TM, vWF:Ag, and DD in patients with PVT were significantly higher than those in patients without PVT (20.68±1.49 vs 13.05±0.97 μg/L, P<0.05; 47.24±1.36 vs 34.05±5.03 μg/L, P<0.05; 194.32%±7.68% vs 136.21%±3.68%, P<0.05; 0.86±0.12 vs 0.42±0.08 mg/L, P<0.05). The plasma levels of GMP-140, TM, vWF:Ag, and DD in PVT patients with severe esophageal varices were significantly higher than those in patients with mild esophageal varices (19.68±1.29 vs 12.05±1.07 μg/L, P<0.05; 45.24±1.26 vs 3505±4.83 μg/L, P<0.05; 196.32%±6.68% vs 141.21%±3.45 %, P<0.05; 0.79±0.12 vs 0.36±0.08 mg/L, P<0.05).The plasma levels of GMP-140, TM, vWF:Ag, and DD in PVT patients with gastrointestinal bleeding were significantly higher than those in patients without gastrointestinal bleeding (18.98±1.18 vs 11.98±1.12 μg/L, P<0.01; 46.78±1.35 vs 36.02±4.78 μg/L, P<001; 19732%±6.39% vs 138.21%±4.12 %, P<0.01; 0.81±0.14 vs 0.35±0.12 mg/L, P<0.01). ConclusionThe levels of molecular markers of prethrombotic state can be used to monitor PVT in LC patients. |
---|---|
ISSN: | 1001-5256 1001-5256 |