Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis
ObjectiveTo investigate the levels of molecular markers of prethrombotic state in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) and their significance. MethodsSeventy-two LC patients who were admitted to our hospital from 2011 to 2013 were selected for analysis. Among the patients,...
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Editorial Department of Journal of Clinical Hepatology
2015-03-01
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doaj-7995a6d58b4f4db98cbb9033b25e8a412020-11-24T21:04:08ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562015-03-0131340440610.3969/j.issn.1001-5256.2015.03.022Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosisLU Xiaomin0Department of Gastroenterology, General Hospital of Puyang Oil Field, Puyang Henan 457001, ChinaObjectiveTo investigate the levels of molecular markers of prethrombotic state in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) and their significance. MethodsSeventy-two LC patients who were admitted to our hospital from 2011 to 2013 were selected for analysis. Among the patients, thirty-two were diagnosed with PVT by computed tomography. The plasma levels of granular membrane protein-140 (GMP-140), von Willebrand Factor antigen (vWF:Ag), thrombomodulin (TM), and D-dimer (DD) were measured by enzyme-linked immunosorbent assay. The data were analyzed using SPSS 11.0. Continuous data were expressed as mean ± standard deviation and compared between the two groups by independent-samples t test. ResultsThe concentrations of GMP-140, TM, vWF:Ag, and DD in patients with PVT were significantly higher than those in patients without PVT (20.68±1.49 vs 13.05±0.97 μg/L, P<0.05; 47.24±1.36 vs 34.05±5.03 μg/L, P<0.05; 194.32%±7.68% vs 136.21%±3.68%, P<0.05; 0.86±0.12 vs 0.42±0.08 mg/L, P<0.05). The plasma levels of GMP-140, TM, vWF:Ag, and DD in PVT patients with severe esophageal varices were significantly higher than those in patients with mild esophageal varices (19.68±1.29 vs 12.05±1.07 μg/L, P<0.05; 45.24±1.26 vs 3505±4.83 μg/L, P<0.05; 196.32%±6.68% vs 141.21%±3.45 %, P<0.05; 0.79±0.12 vs 0.36±0.08 mg/L, P<0.05).The plasma levels of GMP-140, TM, vWF:Ag, and DD in PVT patients with gastrointestinal bleeding were significantly higher than those in patients without gastrointestinal bleeding (18.98±1.18 vs 11.98±1.12 μg/L, P<0.01; 46.78±1.35 vs 36.02±4.78 μg/L, P<001; 19732%±6.39% vs 138.21%±4.12 %, P<0.01; 0.81±0.14 vs 0.35±0.12 mg/L, P<0.01). ConclusionThe levels of molecular markers of prethrombotic state can be used to monitor PVT in LC patients.http://www.lcgdbzz.org/qk_content.asp?id=6375&ClassID=212131156liver cirrhosis; hypertensionportal; blood coagulation |
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language |
zho |
format |
Article |
sources |
DOAJ |
author |
LU Xiaomin |
spellingShingle |
LU Xiaomin Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis Linchuang Gandanbing Zazhi liver cirrhosis; hypertension portal; blood coagulation |
author_facet |
LU Xiaomin |
author_sort |
LU Xiaomin |
title |
Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis |
title_short |
Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis |
title_full |
Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis |
title_fullStr |
Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis |
title_full_unstemmed |
Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis |
title_sort |
significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis |
publisher |
Editorial Department of Journal of Clinical Hepatology |
series |
Linchuang Gandanbing Zazhi |
issn |
1001-5256 1001-5256 |
publishDate |
2015-03-01 |
description |
ObjectiveTo investigate the levels of molecular markers of prethrombotic state in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) and their significance. MethodsSeventy-two LC patients who were admitted to our hospital from 2011 to 2013 were selected for analysis. Among the patients, thirty-two were diagnosed with PVT by computed tomography. The plasma levels of granular membrane protein-140 (GMP-140), von Willebrand Factor antigen (vWF:Ag), thrombomodulin (TM), and D-dimer (DD) were measured by enzyme-linked immunosorbent assay. The data were analyzed using SPSS 11.0. Continuous data were expressed as mean ± standard deviation and compared between the two groups by independent-samples t test. ResultsThe concentrations of GMP-140, TM, vWF:Ag, and DD in patients with PVT were significantly higher than those in patients without PVT (20.68±1.49 vs 13.05±0.97 μg/L, P<0.05; 47.24±1.36 vs 34.05±5.03 μg/L, P<0.05; 194.32%±7.68% vs 136.21%±3.68%, P<0.05; 0.86±0.12 vs 0.42±0.08 mg/L, P<0.05). The plasma levels of GMP-140, TM, vWF:Ag, and DD in PVT patients with severe esophageal varices were significantly higher than those in patients with mild esophageal varices (19.68±1.29 vs 12.05±1.07 μg/L, P<0.05; 45.24±1.26 vs 3505±4.83 μg/L, P<0.05; 196.32%±6.68% vs 141.21%±3.45 %, P<0.05; 0.79±0.12 vs 0.36±0.08 mg/L, P<0.05).The plasma levels of GMP-140, TM, vWF:Ag, and DD in PVT patients with gastrointestinal bleeding were significantly higher than those in patients without gastrointestinal bleeding (18.98±1.18 vs 11.98±1.12 μg/L, P<0.01; 46.78±1.35 vs 36.02±4.78 μg/L, P<001; 19732%±6.39% vs 138.21%±4.12 %, P<0.01; 0.81±0.14 vs 0.35±0.12 mg/L, P<0.01). ConclusionThe levels of molecular markers of prethrombotic state can be used to monitor PVT in LC patients. |
topic |
liver cirrhosis; hypertension portal; blood coagulation |
url |
http://www.lcgdbzz.org/qk_content.asp?id=6375&ClassID=212131156 |
work_keys_str_mv |
AT luxiaomin significanceofmolecularmarkersofprethromboticstateinmonitoringportalveinthrombosisinpatientswithlivercirrhosis |
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