Significance of molecular markers of prethrombotic state in monitoring portal vein thrombosis in patients with liver cirrhosis

• Main Author: LU Xiaomin
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2015-03-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: liver cirrhosis; hypertension; portal; blood coagulation
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=6375&ClassID=212131156

ObjectiveTo investigate the levels of molecular markers of prethrombotic state in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) and their significance. MethodsSeventy-two LC patients who were admitted to our hospital from 2011 to 2013 were selected for analysis. Among the patients, thirty-two were diagnosed with PVT by computed tomography. The plasma levels of granular membrane protein-140 (GMP-140), von Willebrand Factor antigen (vWF:Ag), thrombomodulin (TM), and D-dimer (DD) were measured by enzyme-linked immunosorbent assay. The data were analyzed using SPSS 11.0. Continuous data were expressed as mean ± standard deviation and compared between the two groups by independent-samples t test. ResultsThe concentrations of GMP-140, TM, vWF:Ag, and DD in patients with PVT were significantly higher than those in patients without PVT (20.68±1.49 vs 13.05±0.97 μg/L, P＜0.05; 47.24±1.36 vs 34.05±5.03 μg/L, P＜0.05; 194.32%±7.68% vs 136.21%±3.68%, P＜0.05; 0.86±0.12 vs 0.42±0.08 mg/L, P＜0.05). The plasma levels of GMP-140, TM, vWF:Ag, and DD in PVT patients with severe esophageal varices were significantly higher than those in patients with mild esophageal varices (19.68±1.29 vs 12.05±1.07 μg/L, P＜0.05; 45.24±1.26 vs 3505±4.83 μg/L, P＜0.05; 196.32%±6.68% vs 141.21%±3.45 %, P＜0.05; 0.79±0.12 vs 0.36±0.08 mg/L, P＜0.05).The plasma levels of GMP-140, TM, vWF:Ag, and DD in PVT patients with gastrointestinal bleeding were significantly higher than those in patients without gastrointestinal bleeding (18.98±1.18 vs 11.98±1.12 μg/L, P＜0.01; 46.78±1.35 vs 36.02±4.78 μg/L, P＜001; 19732%±6.39% vs 138.21%±4.12 %, P＜0.01; 0.81±0.14 vs 0.35±0.12 mg/L, P＜0.01). ConclusionThe levels of molecular markers of prethrombotic state can be used to monitor PVT in LC patients.