Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice
We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were treated with either deguelin (5.0 or 10.0 mg/kg body weight, by gavage) or silibinin at doses of 0.05% a...
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2005-12-01
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doaj-799ced76446e4760b436f51aed1edecb2020-11-24T22:47:16ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022005-12-017121053105710.1593/neo.05532Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J MiceYing Yan0Yian Wang1Qing Tan2Ronald A. Lubet3Ming You4Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USADepartment of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USADepartment of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USADivision of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USADepartment of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were treated with either deguelin (5.0 or 10.0 mg/kg body weight, by gavage) or silibinin at doses of 0.05% and 0.1% in the diet, approximately 10 days before a single intraperitoneal dose of BP. We found that oral administration of deguelin reduced tumor multiplicity by 56% and tumor load by 78%, whereas silibinin treatment at doses of 0.05% and 0.1% in the diet did not show any significant efficacy on either tumor multiplicity or tumor load. The result indicates that deguelin significantly inhibits pulmonary adenoma formation and growth in A/J mice. Finding new and effective agents that can prevent lung cancer is urgently needed because cancer of the lungs remains the principal cause of cancer deaths in the United States and because effective chemoprevention of this cancer type remains elusive. Thus, deguelin appears to be a promising new preventive agent for lung cancer and may be considered for further studies in other animal models and in clinical trials. http://www.sciencedirect.com/science/article/pii/S1476558605800417Chemopreventiondeguelinsilibininlung cancerA/J mice |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Yan Yian Wang Qing Tan Ronald A. Lubet Ming You |
spellingShingle |
Ying Yan Yian Wang Qing Tan Ronald A. Lubet Ming You Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice Neoplasia: An International Journal for Oncology Research Chemoprevention deguelin silibinin lung cancer A/J mice |
author_facet |
Ying Yan Yian Wang Qing Tan Ronald A. Lubet Ming You |
author_sort |
Ying Yan |
title |
Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice |
title_short |
Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice |
title_full |
Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice |
title_fullStr |
Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice |
title_full_unstemmed |
Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice |
title_sort |
efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in a/j mice |
publisher |
Elsevier |
series |
Neoplasia: An International Journal for Oncology Research |
issn |
1476-5586 1522-8002 |
publishDate |
2005-12-01 |
description |
We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were treated with either deguelin (5.0 or 10.0 mg/kg body weight, by gavage) or silibinin at doses of 0.05% and 0.1% in the diet, approximately 10 days before a single intraperitoneal dose of BP. We found that oral administration of deguelin reduced tumor multiplicity by 56% and tumor load by 78%, whereas silibinin treatment at doses of 0.05% and 0.1% in the diet did not show any significant efficacy on either tumor multiplicity or tumor load. The result indicates that deguelin significantly inhibits pulmonary adenoma formation and growth in A/J mice. Finding new and effective agents that can prevent lung cancer is urgently needed because cancer of the lungs remains the principal cause of cancer deaths in the United States and because effective chemoprevention of this cancer type remains elusive. Thus, deguelin appears to be a promising new preventive agent for lung cancer and may be considered for further studies in other animal models and in clinical trials.
|
topic |
Chemoprevention deguelin silibinin lung cancer A/J mice |
url |
http://www.sciencedirect.com/science/article/pii/S1476558605800417 |
work_keys_str_mv |
AT yingyan efficacyofdeguelinandsilibininonbenzoapyreneinducedlungtumorigenesisinajmice AT yianwang efficacyofdeguelinandsilibininonbenzoapyreneinducedlungtumorigenesisinajmice AT qingtan efficacyofdeguelinandsilibininonbenzoapyreneinducedlungtumorigenesisinajmice AT ronaldalubet efficacyofdeguelinandsilibininonbenzoapyreneinducedlungtumorigenesisinajmice AT mingyou efficacyofdeguelinandsilibininonbenzoapyreneinducedlungtumorigenesisinajmice |
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