Synthesis and Antitumor Evaluation of Novel Dihydropyrimidine, Thiazolo[3,2-a]Pyrimidine and Pyrano[2,3-d]Pyrimidine Derivatives

Synthesis and Antitumor Evaluation of Novel Dihydropyrimidine, Thiazolo[3,2-a]Pyrimidine and Pyrano[2,3-d]Pyrimidine Derivatives

A simple and efficient method has been developed for the synthesis of 4,5-dihydro-2-mercapto-4-oxo-6-substituted arylpyrimidine derivatives (2a-e) and their fused rings (3b, 4b, 5b & 6b) and also 1,4-dihydro-2-mercaptopyrimidine derivatives (7a-e) & (9a-e) using triethylamine as a catalyst....

Full description

Bibliographic Details
Main Author:	Nadia Y. Megally Abdo
Format:	Article
Language:	English
Published:	Slovenian Chemical Society 2015-01-01
Series:	Acta Chimica Slovenica
Subjects:	4,5-dihydro pyrimidine 1,4- dihydropyrimidine Thiazolo[3,2-a]pyrimidine pyrano[2,3-d]pyrimidine anticancer activity
Online Access:	https://journals.matheo.si/index.php/ACSi/article/view/867

Similar Items

Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives
by: Dong Cai, et al.
Published: (2015-09-01)

Preparation of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one derivatives using MgO-MgAl2O4 composite nano-powder
by: Mehdi Khalaj
Published: (2020-08-01)

Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives
by: A. H. Bedair, et al.
Published: (2001-05-01)

Synthesis and Ab Initio Study of Pyrano[2,3-d]pyrimidine Derivatives
by: Masoumeh Shahi, et al.
Published: (2014-03-01)

Crystal structure of ethyl 2-cyano-3-[(1-ethoxyethylidene)amino]-5-(3-methoxyphenyl)-7-methyl-5H-1,3-thiazolo[3,2-a]pyrimidine-6-carboxylate
by: M. S. Krishnamurthy, et al.
Published: (2015-04-01)

Synthesis of thiazolo- and benzothiazolo[3,2-a]pyrimidine derivatives using onion peel as natural catalyst
by: Sian Hui Tan, et al.
Published: (2020-02-01)

Clean Synthesis of Pyrano[2,3- D]Pyrimidines Using ZnO Nano-Powders
by: Maleki Nariman, et al.
Published: (2016-07-01)

Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives
by: Yogesh S. Patel, et al.
Published: (2017-10-01)

p-TSA-promoted syntheses of 5H-benzo[h]thiazolo[2,3-b]quinazoline and indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma
by: Keshari AK, et al.
Published: (2017-05-01)

Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives
by: Sheikhan-Shamsabadi Nafisehsadat, et al.
Published: (2017-04-01)

Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous media
by: Ajmal R. Bhat, et al.
Published: (2017-01-01)

Ethyl (1,3-diphenyl-1H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)acetate
by: Sobhi M. Gomha, et al.
Published: (2011-11-01)

1-Methyl-3-(2-methylphenyl)-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine
by: Mohamed El Hafi, et al.
Published: (2017-10-01)

Nano-SiO2 catalyzed three-component preparations of pyrano[2,3-d]pyrimidines, 4H-chromenes, and dihydropyrano[3,2-c]chromenes
by: Ebrahim Mollashahi, et al.
Published: (2018-01-01)

Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents
by: Hafez Hend N., et al.
Published: (2017-09-01)

Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives
by: Vaghasia S.J., et al.
Published: (2007-01-01)

Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives
by: S. J. VAGHASIA, et al.
Published: (2007-02-01)

Iron Ore Pellet, A Natural and Reusable Catalyst for Synthesis of Pyrano[2,3-d]pyrimidine and Dihydropyrano[c]chromene Derivatives in Aqueous Media
by: Enayatollah Sheikhhosseini, et al.
Published: (2016-02-01)

Crystal structure of (2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-3-yl)(phenyl)methanone
by: T. Sankar, et al.
Published: (2015-05-01)

Visible light irradiation promoted catalyst-free and solvent-free synthesis of pyrano[2,3-d]pyrimidine scaffolds at room temperature
by: Farzaneh Mohamadpour
Published: (2020-08-01)

In Plane Vibration of Pyrimidine and some Deuterated Pyrimidines
by: F. Milani Nejad,
Published: (1991-06-01)

4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine
by: Eun Sun Noh, et al.
Published: (2020-05-01)

2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation
by: Hualiang Jiang, et al.
Published: (2009-02-01)

Pyrimidine Metabolism in Rhizobium: Physiological Aspects of Pyrimidine Salvage
by: Ibrahim, Mohamed M.
Published: (1989)

Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]- triazolo[1,5-c]pyrimidine Derivatives
by: Omar A. Miqdad, et al.
Published: (2008-07-01)

Synthesis of some pyrazolo[3,4-d]pyrimidines and their fused triazole and tetrazole derivatives
by: Swelam Samira A., et al.
Published: (1999-01-01)

Synthesis of some pyrazolo[3,4-d]pyrimidines and their fused triazole and tetrazole derivatives
by: MAGDI E. A. ZAKI, et al.
Published: (1999-11-01)

Design, Synthesis, and Biological Activity of Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine Derivatives as Anti-Inflammatory Agents
by: Yuan Zhang, et al.
Published: (2017-11-01)

Pyrimidine Genes in Pseudomonas Species
by: Roush, Wendy A.
Published: (2003)

Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
by: Reda M. Abdelhameed, et al.
Published: (2020-09-01)

Simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial activities
by: Hafez Hend N., et al.
Published: (2016-09-01)

Synthesis of Certain Pyrimidine Derivatives as Antimicrobial Agents and Anti-Inflammatory Agents
by: Amira Ibrahim Sayed, et al.
Published: (2010-03-01)

Synthesis of Functionalized Dihydropyrido[2,3-d]pyrimidines in Aqueous Medium
by: Saeed Balalaie, et al.
Published: (2018-01-01)

Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives
by: Hafez Hend N., et al.
Published: (2017-12-01)

Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.
by: Hildick, Brian G.
Published: (2010)

Electrochemical behavior of some new pyrimidine derivatives
by: Kiliç Hasan, et al.
Published: (2004-01-01)

Electrochemical behavior of some new pyrimidine derivatives
by: MUSTAFA LUTFU BERKEM, et al.
Published: (2004-09-01)

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
by: Hussein El-Kashef, et al.
Published: (2010-04-01)

Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3′,2′:4,5]furo(thieno)[3,2-<i>d</i>]pyrimidin-8-amines
by: Samvel N. Sirakanyan, et al.
Published: (2019-10-01)

Synthesis of 2,4-Disubstituted Pyrimidine Derivatives as Potential 5-HT7 Receptor Antagonist.
by: Sullivan, Shannon M.
Published: (2008)