Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions

Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions

Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary...

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Bibliographic Details
Main Authors: Gianluca Businello, Valentina Angerilli, Paola Parente, Stefano Realdon, Edoardo Savarino, Fabio Farinati, Federica Grillo, Alessandro Vanoli, Francesca Galuppini, Silvia Paccagnella, Gianmaria Pennelli, Luca Mastracci, Luca Saragoni, Matteo Fassan
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
gastric carcinoma
pre-neoplastic lesions
gastric carcinogenesis
biomarkers
pathology
Online Access:https://www.mdpi.com/1422-0067/22/18/9950
Description
Summary:Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary prevention. In recent years, a large amount of data about the molecular events in GC development is emerging, flanking the histomorphological descriptions. In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process.
ISSN:1661-6596
1422-0067

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