Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance.10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent...

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Bibliographic Details
Main Authors: Hasna Hamdaoui, Abdelhafid Natiq, Oumaima Benlarroubia, Thomas Liehr, Hind Dehbi, Latifa Loukhmas, Fatima Chegdani
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Leukemia Research Reports
Subjects:
Multiple myeloma
AL amyloidosis
cytogenetic analysis
FISH
IGH/FGFR3
del 17p
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048920300236
Description
Summary:Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance.10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent multiple myeloma.This study of MM case in which we found a near tetraploid complex karyotype with the t(11;14) (q13;q32) abnormality in cytogenetic analysis and the presence of t(4;14) and del(17p) by iFISH, referred to several studies which showed the translocation t(11;14) as the most frequent abnormality in both AL amyloidosis and MM.
ISSN:2213-0489

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