Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance.10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent...

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Main Authors: Hasna Hamdaoui, Abdelhafid Natiq, Oumaima Benlarroubia, Thomas Liehr, Hind Dehbi, Latifa Loukhmas, Fatima Chegdani
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Leukemia Research Reports
Subjects:
Multiple myeloma
AL amyloidosis
cytogenetic analysis
FISH
IGH/FGFR3
del 17p
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048920300236
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spelling doaj-79b6edd44a2b4de29cc55211c35bea792020-12-19T05:05:48ZengElsevierLeukemia Research Reports2213-04892020-01-0114100217Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myelomaHasna Hamdaoui0Abdelhafid Natiq1Oumaima Benlarroubia2Thomas Liehr3Hind Dehbi4Latifa Loukhmas5Fatima Chegdani6National Reference Laboratory, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco; University Hassan II Casablanca, Faculty of sciences Ain Chock Casablanca, Morocco; Corresponding author at: National Reference Laboratory, Cheikh Khalifa International Hospital, BP82403 Oum rabii, Hay hassani, Bvd Mohammed Tayeb Naciri, Casablanca, Morocco.Département de génétique médicale, Institut national d'hygiène, Rabat, MoroccoNational Reference Laboratory, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MoroccoDepartment of Medical Genetics, University of Jena, Institute for Humangenetics, D-07740 Jena, GermanyLaboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II, Casablanca, MoroccoCheikh Khalifa International Hospital, Casablanca, MoroccoUniversity Hassan II Casablanca, Faculty of sciences Ain Chock Casablanca, MoroccoCytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance.10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent multiple myeloma.This study of MM case in which we found a near tetraploid complex karyotype with the t(11;14) (q13;q32) abnormality in cytogenetic analysis and the presence of t(4;14) and del(17p) by iFISH, referred to several studies which showed the translocation t(11;14) as the most frequent abnormality in both AL amyloidosis and MM.http://www.sciencedirect.com/science/article/pii/S2213048920300236Multiple myelomaAL amyloidosiscytogenetic analysisFISHIGH/FGFR3del 17p
collection DOAJ
language English
format Article
sources DOAJ
author Hasna Hamdaoui
Abdelhafid Natiq
Oumaima Benlarroubia
Thomas Liehr
Hind Dehbi
Latifa Loukhmas
Fatima Chegdani
spellingShingle Hasna Hamdaoui
Abdelhafid Natiq
Oumaima Benlarroubia
Thomas Liehr
Hind Dehbi
Latifa Loukhmas
Fatima Chegdani
Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
Leukemia Research Reports
Multiple myeloma
AL amyloidosis
cytogenetic analysis
FISH
IGH/FGFR3
del 17p
author_facet Hasna Hamdaoui
Abdelhafid Natiq
Oumaima Benlarroubia
Thomas Liehr
Hind Dehbi
Latifa Loukhmas
Fatima Chegdani
author_sort Hasna Hamdaoui
title Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_short Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_full Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_fullStr Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_full_unstemmed Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_sort near tetrapoloid karyotype with translocation t(11;14) in a moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2020-01-01
description Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance.10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent multiple myeloma.This study of MM case in which we found a near tetraploid complex karyotype with the t(11;14) (q13;q32) abnormality in cytogenetic analysis and the presence of t(4;14) and del(17p) by iFISH, referred to several studies which showed the translocation t(11;14) as the most frequent abnormality in both AL amyloidosis and MM.
topic Multiple myeloma
AL amyloidosis
cytogenetic analysis
FISH
IGH/FGFR3
del 17p
url http://www.sciencedirect.com/science/article/pii/S2213048920300236
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