Dendritic Cells-Nature and Classification

Dendritic Cells-Nature and Classification

Dendritic cells (DCs) are antigen (Ag)-presenting cells (APCs) characterized by a unique capacity to stimulate naïve T cells and initiate primary immune responses. Recent studies suggest that DCs also play critical roles in the induction of central and peripheral immunological tolerance, regulate th...

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Bibliographic Details
Main Authors: Katsuaki Sato, Shigeharu Fujita
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Allergology International
Subjects:
Dendritic cells
Development
Functional plasticity
Immune response
Lineage
Subset heterogeneity
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015308649
Description
Summary:Dendritic cells (DCs) are antigen (Ag)-presenting cells (APCs) characterized by a unique capacity to stimulate naïve T cells and initiate primary immune responses. Recent studies suggest that DCs also play critical roles in the induction of central and peripheral immunological tolerance, regulate the types of T cell immune responses, and function as sentinels in innate immunity against microbes. The diverse functions of DCs in immune regulation depend on the heterogeneity of DC subsets and their functional plasticity. Here we review recent progress in our understanding of the nature and classification of DCs.
ISSN:1323-8930

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