Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study
Abstract Background The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. Methods Cases were child...
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Online Access: | http://link.springer.com/article/10.1186/s12889-016-3690-9 |
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doaj-79bbfdce5e9440ecaf010dfed514cf602020-11-24T21:41:41ZengBMCBMC Public Health1471-24582016-09-0116111010.1186/s12889-016-3690-9Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control studyF. Balazard0S. Le Fur1S. Valtat2A. J. Valleron3P. Bougnères4Isis-Diab collaborative groupDominique ThevenieauCorinne Fourmy ChatelRachel DesailloudHélène Bony-TrifunovicPierre-Henri DucluzeauRégis CoutantSophie CaudrelierArmelle PambouEmmanuelle DubosclardFlorence JoubertPhilippe JanEstelle MarcouxAnne-Marie BertrandBrigitte MignotAlfred PenformisChantal StuckensRégis PiquemalPascal BaratVincent RigalleauChantal StheneurSylviane FournierVéronique KerlanChantal MetzAnne Fargeot-EspaliatYves ReznicFrédérique OlivierIva GueorguievaArnaud MonierCatherine RadetVincent GajdosDaniel TerralChristine VervelDjamel BendifallahCandace Ben SignorDaniel DervauxAbdelkader BenmahammedGuy-André LoeuilleFrançoise PopelardAgnès GuillouPierre-Yves BenhamouJamil KhouryJean-Pierre BrossierJoachim BassilSylvaine ClavelBernard Le LuyerPierre BougnèresFrançoise LabayIsabelle GuemasJacques WeillJean-Pierre CappoenSylvie NadalonAnne Lienhardt-RoussieAnne PaoliClaudie KerouedanEdwige YollinMarc NicolinoGilbert SimoninJacques CohenCatherine AtlanAgnès TambouraHervé DubourgMarie-Laure PignolPhilippe TalonStéphanie JellimannLucy ChaillousSabine BaronMarie-Noëlle BortoluzziElisabeth BaechlerRanda SaletAriane Zelinsky-GurungFabienne DallavaleEtienne LargerMarie Laloi-MichelinJean-François GautierBénédicte GuérinLaure OilleauLaetitia PantaloneCéline LukasIsabelle GuilhemMarc De KerdanetMarie-Claire WielickzoMélanie Priou-GuesdonOdile RichardFrançois KurtzNorbert LaisneyDéborah AncelleGuilhem ParlierCatherine BonifaceDominique Paris BockelDenis DufillotBerthe RazafimahefaPierre GourdyPierre LecomteMyriam Pepin-DonatMarie-Emmanuelle Combes-MoukhovskyBrigitte ZymmermannMarina RaoulxAnne Gourdin et Catherine DumontSorbonne Universités, UPMC Univ Paris 06, CNRSINSERM U1169, Hôpital Bicêtre, Université Paris-SudINSERM U1169, Hôpital Bicêtre, Université Paris-SudINSERM U1169, Hôpital Bicêtre, Université Paris-SudINSERM U1169, Hôpital Bicêtre, Université Paris-SudAbstract Background The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. Methods Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods. Results We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age. Conclusions The found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas. Trial registration Clinical-Trial.gov NCT02212522 . Registered August 6, 2014. http://link.springer.com/article/10.1186/s12889-016-3690-9Case–controlEpidemiologyType 1 diabetesData-drivenEnvironment |
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language |
English |
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DOAJ |
author |
F. Balazard S. Le Fur S. Valtat A. J. Valleron P. Bougnères Isis-Diab collaborative group Dominique Thevenieau Corinne Fourmy Chatel Rachel Desailloud Hélène Bony-Trifunovic Pierre-Henri Ducluzeau Régis Coutant Sophie Caudrelier Armelle Pambou Emmanuelle Dubosclard Florence Joubert Philippe Jan Estelle Marcoux Anne-Marie Bertrand Brigitte Mignot Alfred Penformis Chantal Stuckens Régis Piquemal Pascal Barat Vincent Rigalleau Chantal Stheneur Sylviane Fournier Véronique Kerlan Chantal Metz Anne Fargeot-Espaliat Yves Reznic Frédérique Olivier Iva Gueorguieva Arnaud Monier Catherine Radet Vincent Gajdos Daniel Terral Christine Vervel Djamel Bendifallah Candace Ben Signor Daniel Dervaux Abdelkader Benmahammed Guy-André Loeuille Françoise Popelard Agnès Guillou Pierre-Yves Benhamou Jamil Khoury Jean-Pierre Brossier Joachim Bassil Sylvaine Clavel Bernard Le Luyer Pierre Bougnères Françoise Labay Isabelle Guemas Jacques Weill Jean-Pierre Cappoen Sylvie Nadalon Anne Lienhardt-Roussie Anne Paoli Claudie Kerouedan Edwige Yollin Marc Nicolino Gilbert Simonin Jacques Cohen Catherine Atlan Agnès Tamboura Hervé Dubourg Marie-Laure Pignol Philippe Talon Stéphanie Jellimann Lucy Chaillous Sabine Baron Marie-Noëlle Bortoluzzi Elisabeth Baechler Randa Salet Ariane Zelinsky-Gurung Fabienne Dallavale Etienne Larger Marie Laloi-Michelin Jean-François Gautier Bénédicte Guérin Laure Oilleau Laetitia Pantalone Céline Lukas Isabelle Guilhem Marc De Kerdanet Marie-Claire Wielickzo Mélanie Priou-Guesdon Odile Richard François Kurtz Norbert Laisney Déborah Ancelle Guilhem Parlier Catherine Boniface Dominique Paris Bockel Denis Dufillot Berthe Razafimahefa Pierre Gourdy Pierre Lecomte Myriam Pepin-Donat Marie-Emmanuelle Combes-Moukhovsky Brigitte Zymmermann Marina Raoulx Anne Gourdin et Catherine Dumont |
spellingShingle |
F. Balazard S. Le Fur S. Valtat A. J. Valleron P. Bougnères Isis-Diab collaborative group Dominique Thevenieau Corinne Fourmy Chatel Rachel Desailloud Hélène Bony-Trifunovic Pierre-Henri Ducluzeau Régis Coutant Sophie Caudrelier Armelle Pambou Emmanuelle Dubosclard Florence Joubert Philippe Jan Estelle Marcoux Anne-Marie Bertrand Brigitte Mignot Alfred Penformis Chantal Stuckens Régis Piquemal Pascal Barat Vincent Rigalleau Chantal Stheneur Sylviane Fournier Véronique Kerlan Chantal Metz Anne Fargeot-Espaliat Yves Reznic Frédérique Olivier Iva Gueorguieva Arnaud Monier Catherine Radet Vincent Gajdos Daniel Terral Christine Vervel Djamel Bendifallah Candace Ben Signor Daniel Dervaux Abdelkader Benmahammed Guy-André Loeuille Françoise Popelard Agnès Guillou Pierre-Yves Benhamou Jamil Khoury Jean-Pierre Brossier Joachim Bassil Sylvaine Clavel Bernard Le Luyer Pierre Bougnères Françoise Labay Isabelle Guemas Jacques Weill Jean-Pierre Cappoen Sylvie Nadalon Anne Lienhardt-Roussie Anne Paoli Claudie Kerouedan Edwige Yollin Marc Nicolino Gilbert Simonin Jacques Cohen Catherine Atlan Agnès Tamboura Hervé Dubourg Marie-Laure Pignol Philippe Talon Stéphanie Jellimann Lucy Chaillous Sabine Baron Marie-Noëlle Bortoluzzi Elisabeth Baechler Randa Salet Ariane Zelinsky-Gurung Fabienne Dallavale Etienne Larger Marie Laloi-Michelin Jean-François Gautier Bénédicte Guérin Laure Oilleau Laetitia Pantalone Céline Lukas Isabelle Guilhem Marc De Kerdanet Marie-Claire Wielickzo Mélanie Priou-Guesdon Odile Richard François Kurtz Norbert Laisney Déborah Ancelle Guilhem Parlier Catherine Boniface Dominique Paris Bockel Denis Dufillot Berthe Razafimahefa Pierre Gourdy Pierre Lecomte Myriam Pepin-Donat Marie-Emmanuelle Combes-Moukhovsky Brigitte Zymmermann Marina Raoulx Anne Gourdin et Catherine Dumont Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study BMC Public Health Case–control Epidemiology Type 1 diabetes Data-driven Environment |
author_facet |
F. Balazard S. Le Fur S. Valtat A. J. Valleron P. Bougnères Isis-Diab collaborative group Dominique Thevenieau Corinne Fourmy Chatel Rachel Desailloud Hélène Bony-Trifunovic Pierre-Henri Ducluzeau Régis Coutant Sophie Caudrelier Armelle Pambou Emmanuelle Dubosclard Florence Joubert Philippe Jan Estelle Marcoux Anne-Marie Bertrand Brigitte Mignot Alfred Penformis Chantal Stuckens Régis Piquemal Pascal Barat Vincent Rigalleau Chantal Stheneur Sylviane Fournier Véronique Kerlan Chantal Metz Anne Fargeot-Espaliat Yves Reznic Frédérique Olivier Iva Gueorguieva Arnaud Monier Catherine Radet Vincent Gajdos Daniel Terral Christine Vervel Djamel Bendifallah Candace Ben Signor Daniel Dervaux Abdelkader Benmahammed Guy-André Loeuille Françoise Popelard Agnès Guillou Pierre-Yves Benhamou Jamil Khoury Jean-Pierre Brossier Joachim Bassil Sylvaine Clavel Bernard Le Luyer Pierre Bougnères Françoise Labay Isabelle Guemas Jacques Weill Jean-Pierre Cappoen Sylvie Nadalon Anne Lienhardt-Roussie Anne Paoli Claudie Kerouedan Edwige Yollin Marc Nicolino Gilbert Simonin Jacques Cohen Catherine Atlan Agnès Tamboura Hervé Dubourg Marie-Laure Pignol Philippe Talon Stéphanie Jellimann Lucy Chaillous Sabine Baron Marie-Noëlle Bortoluzzi Elisabeth Baechler Randa Salet Ariane Zelinsky-Gurung Fabienne Dallavale Etienne Larger Marie Laloi-Michelin Jean-François Gautier Bénédicte Guérin Laure Oilleau Laetitia Pantalone Céline Lukas Isabelle Guilhem Marc De Kerdanet Marie-Claire Wielickzo Mélanie Priou-Guesdon Odile Richard François Kurtz Norbert Laisney Déborah Ancelle Guilhem Parlier Catherine Boniface Dominique Paris Bockel Denis Dufillot Berthe Razafimahefa Pierre Gourdy Pierre Lecomte Myriam Pepin-Donat Marie-Emmanuelle Combes-Moukhovsky Brigitte Zymmermann Marina Raoulx Anne Gourdin et Catherine Dumont |
author_sort |
F. Balazard |
title |
Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
title_short |
Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
title_full |
Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
title_fullStr |
Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
title_full_unstemmed |
Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
title_sort |
association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study |
publisher |
BMC |
series |
BMC Public Health |
issn |
1471-2458 |
publishDate |
2016-09-01 |
description |
Abstract Background The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown. The purpose of the study was to unravel environmental markers associated with T1D. Methods Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods. Results We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age. Conclusions The found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas. Trial registration Clinical-Trial.gov NCT02212522 . Registered August 6, 2014. |
topic |
Case–control Epidemiology Type 1 diabetes Data-driven Environment |
url |
http://link.springer.com/article/10.1186/s12889-016-3690-9 |
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associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT deborahancelle associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT guilhemparlier associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT catherineboniface associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT dominiqueparisbockel associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT denisdufillot associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT bertherazafimahefa associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT pierregourdy associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT pierrelecomte associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT myriampepindonat associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT marieemmanuellecombesmoukhovsky associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT brigittezymmermann associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT marinaraoulx associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy AT annegourdinetcatherinedumont associationofenvironmentalmarkerswithchildhoodtype1diabetesmellitusrevealedbyalongquestionnaireonearlylifeexposuresandlifestyleinacasecontrolstudy |
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