LncRNA SNHG16 promotes tumor growth of pancreatic cancer by targeting miR-218-5p

• Main Authors: Songyang Liu, Wei Zhang, Kai Liu, Yahui Liu
• Format: Article
• Language: English
• Published: Elsevier 2019-06-01
• Series: Biomedicine & Pharmacotherapy
• Subjects: Pancreatic cancer; lncRNA; SNHG16; miR-218-5p; Proliferation; Invasion
• Online Access: http://www.sciencedirect.com/science/article/pii/S0753332219304251

Small Nucleolar RNA Host Gene (SNHG16) is a novel cancer-related long noncoding RNA (lncRNA) and functions as an oncogene in a variety of cancers. Nonetheless, the expression patterns, biological function, and potential mechanisms in SNHG16 in pancreatic cancer (PC) remain rarely known. An increase in expression of SNHG16 in PC samples against adjacent normal tissues was shown here. Increased SNHG16 was linked intimately to the tumor-node-metastasis (TNM) stage, distant metastasis, tumor differentiation, and poor overall survival. Loss-of-function experiments revealed that SNHG16 knockdown suppressed the proliferation, formation of colonies, ability to migrate and invade in vitro, along with a lowered growth of the tumor in a mouse model. Mechanistically, SNHG16 might serve as a sponge competitive endogenous RNA (ceRNA) for miR-218-5p, thereby playing a role in regulating the expression of high mobility group box 1 (HMGB1) expression, a known direct miR-218-5p target in PC cells. These results provide novel insight into PC tumorigenesis and suggest that SNHG16 could serve as a likely therapeutic intervention in PC.