The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial
Objectives: The study was designed to determine the effect of thirty days of pomegranate extract oral supplementation on plasma inflammatory and oxidative stress biomarkers as well as serum metabolic profiles, in overweight and obese individuals. Methods: In this randomized, double-blind, placebo-co...
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Qom University of Medical Sciences
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doaj-79f41a4b79ed4df8b163426727ce1ca52021-08-31T09:24:26ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752019-10-011381425The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trialMeysam Zarezadeh0Ahmad Saedisomeolia1Banafsheh Hosseini2Mohammad Reza Emami3 Department of Cellular & Molecular Nutrition, Faculty of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences Department of Cellular & Molecular Nutrition, Faculty of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences Department of Cellular & Molecular Nutrition, Faculty of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences Department of Clinical Nutrition, Faculty of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences Objectives: The study was designed to determine the effect of thirty days of pomegranate extract oral supplementation on plasma inflammatory and oxidative stress biomarkers as well as serum metabolic profiles, in overweight and obese individuals. Methods: In this randomized, double-blind, placebo-controlled study 48 obese and overweight participants were randomly assigned to receive either 1000 mg of pomegranate extract (PE), or a placebo (PL), daily for 30 days. At baseline, and after 30 days of treatment, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde (MDA), interleukin-6 (IL-6) and hyper sensitive-C reactive protein (hs-CRP) and levels of serum lipids, glucose and insulin were assessed. Results: Thirty days of PE supplementation resulted in a significant decrease in mean serum levels of glucose, insulin, total cholesterol, LDL-C, and plasma MDA, IL-6 and hs-CRP. HDL-C significantly increased following the PE versus the PL intervention. Conclusion: Our study suggests that pomegranate extract consumption may reduce complications linked with obesity through ameliorating the systemic inflammation and lipid profile. Future studies with larger sample size are required to verify these results.http://journal.muq.ac.ir/article-1-2543-en.htmlpunicaceaeobesityinflammationlipid peroxidationrandomized clinical trial. |
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language |
fas |
format |
Article |
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DOAJ |
author |
Meysam Zarezadeh Ahmad Saedisomeolia Banafsheh Hosseini Mohammad Reza Emami |
spellingShingle |
Meysam Zarezadeh Ahmad Saedisomeolia Banafsheh Hosseini Mohammad Reza Emami The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum punicaceae obesity inflammation lipid peroxidation randomized clinical trial. |
author_facet |
Meysam Zarezadeh Ahmad Saedisomeolia Banafsheh Hosseini Mohammad Reza Emami |
author_sort |
Meysam Zarezadeh |
title |
The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial |
title_short |
The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial |
title_full |
The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial |
title_fullStr |
The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial |
title_full_unstemmed |
The effect of Punica Granatum (Pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: A randomized placebo-controlled clinical trial |
title_sort |
effect of punica granatum (pomegranate) extract on inflammatory biomarkers, lipid profile and glycemic indices in patients with overweight and obesity: a randomized placebo-controlled clinical trial |
publisher |
Qom University of Medical Sciences |
series |
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
issn |
1735-7799 2008-1375 |
publishDate |
2019-10-01 |
description |
Objectives: The study was designed to determine the effect of thirty days of pomegranate extract oral supplementation on plasma inflammatory and oxidative stress biomarkers as well as serum metabolic profiles, in overweight and obese individuals.
Methods: In this randomized, double-blind, placebo-controlled study 48 obese and overweight participants were randomly assigned to receive either 1000 mg of pomegranate extract (PE), or a placebo (PL), daily for 30 days. At baseline, and after 30 days of treatment, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde (MDA), interleukin-6 (IL-6) and hyper sensitive-C reactive protein (hs-CRP) and levels of serum lipids, glucose and insulin were assessed.
Results: Thirty days of PE supplementation resulted in a significant decrease in mean serum levels of glucose, insulin, total cholesterol, LDL-C, and plasma MDA, IL-6 and hs-CRP. HDL-C significantly increased following the PE versus the PL intervention.
Conclusion: Our study suggests that pomegranate extract consumption may reduce complications linked with obesity through ameliorating the systemic inflammation and lipid profile. Future studies with larger sample size are required to verify these results. |
topic |
punicaceae obesity inflammation lipid peroxidation randomized clinical trial. |
url |
http://journal.muq.ac.ir/article-1-2543-en.html |
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