Senescent T cells: a potential biomarker and target for cancer therapy
The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector functions, accumulate in ageing, chronic viral infections, and autoimmune disorders where antigen stimulation per...
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doaj-79f490fbbff94266ba04664350a29f1e2021-06-25T04:49:00ZengElsevierEBioMedicine2352-39642021-06-0168103409Senescent T cells: a potential biomarker and target for cancer therapyJie Zhang0Tianhui He1Lixiang Xue2Hongyan Guo3Department of Obstetrics and Gynecology, Peking University Third Hospital, China; Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.; Biobank, Peking University Third Hospital, Beijing, China.Department of Obstetrics and Gynecology, Peking University Third Hospital, ChinaInstitute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.; Biobank, Peking University Third Hospital, Beijing, China.; Corresponding AuthorDepartment of Obstetrics and Gynecology, Peking University Third Hospital, China; Corresponding AuthorThe failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector functions, accumulate in ageing, chronic viral infections, and autoimmune disorders where antigen stimulation persists. Increasing evidence suggests that inducing T cell senescence is a key strategy used by malignant tumours to evade immune surveillance. In this review, we summarize the general features, functional regulation, and signalling network of senescent T cells in tumour development and highlight their potential as prognostic biomarkers in multiple cancer treatments, including chemotherapy, radiotherapy, and immunotherapy. Moreover, we discuss possible therapeutic strategies for preventing or rejuvenating senescence in tumour-specific T cells. Understanding these critical issues may provide novel strategies to enhance cancer immunotherapy.http://www.sciencedirect.com/science/article/pii/S2352396421002024Senescent T celltumour microenvironmentcancer immunotherapyprognostic biomarkerstherapeutic targets |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jie Zhang Tianhui He Lixiang Xue Hongyan Guo |
spellingShingle |
Jie Zhang Tianhui He Lixiang Xue Hongyan Guo Senescent T cells: a potential biomarker and target for cancer therapy EBioMedicine Senescent T cell tumour microenvironment cancer immunotherapy prognostic biomarkers therapeutic targets |
author_facet |
Jie Zhang Tianhui He Lixiang Xue Hongyan Guo |
author_sort |
Jie Zhang |
title |
Senescent T cells: a potential biomarker and target for cancer therapy |
title_short |
Senescent T cells: a potential biomarker and target for cancer therapy |
title_full |
Senescent T cells: a potential biomarker and target for cancer therapy |
title_fullStr |
Senescent T cells: a potential biomarker and target for cancer therapy |
title_full_unstemmed |
Senescent T cells: a potential biomarker and target for cancer therapy |
title_sort |
senescent t cells: a potential biomarker and target for cancer therapy |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2021-06-01 |
description |
The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector functions, accumulate in ageing, chronic viral infections, and autoimmune disorders where antigen stimulation persists. Increasing evidence suggests that inducing T cell senescence is a key strategy used by malignant tumours to evade immune surveillance. In this review, we summarize the general features, functional regulation, and signalling network of senescent T cells in tumour development and highlight their potential as prognostic biomarkers in multiple cancer treatments, including chemotherapy, radiotherapy, and immunotherapy. Moreover, we discuss possible therapeutic strategies for preventing or rejuvenating senescence in tumour-specific T cells. Understanding these critical issues may provide novel strategies to enhance cancer immunotherapy. |
topic |
Senescent T cell tumour microenvironment cancer immunotherapy prognostic biomarkers therapeutic targets |
url |
http://www.sciencedirect.com/science/article/pii/S2352396421002024 |
work_keys_str_mv |
AT jiezhang senescenttcellsapotentialbiomarkerandtargetforcancertherapy AT tianhuihe senescenttcellsapotentialbiomarkerandtargetforcancertherapy AT lixiangxue senescenttcellsapotentialbiomarkerandtargetforcancertherapy AT hongyanguo senescenttcellsapotentialbiomarkerandtargetforcancertherapy |
_version_ |
1721360634564575232 |