Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation

Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation

Summary: Astrocytic contributions to neuroinflammation are widely implicated in disease, but they remain incompletely explored. We assess medial prefrontal cortex (PFC) and visual cortex (VCX) astrocyte and whole-tissue gene expression changes in mice following peripherally induced neuroinflammation...

Full description

Bibliographic Details
Main Authors:	Blanca Diaz-Castro, Alexander M. Bernstein, Giovanni Coppola, Michael V. Sofroniew, Baljit S. Khakh
Format:	Article
Language:	English
Published:	Elsevier 2021-08-01
Series:	Cell Reports
Subjects:	astrocyte neuroinflammation LPS prefrontal cortex astrocyte reactivity RNA-seq
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124721009384

Similar Items

Interaction of Microglia and Astrocytes in the Neurovascular Unit
by: Li-rong Liu, et al.
Published: (2020-07-01)

Lipopolysaccharide-Induced Matrix Metalloproteinase-9 Expression Associated with Cell Migration in Rat Brain Astrocytes
by: Chien-Chung Yang, et al.
Published: (2019-12-01)

Involvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axis
by: Ying Tang, et al.
Published: (2021-03-01)

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling
by: Ka-Young Ryu, et al.
Published: (2019-10-01)

α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin
by: Mingju Cao, et al.
Published: (2019-05-01)

Absence of BBSome function leads to astrocyte reactivity in the brain
by: Minati Singh, et al.
Published: (2019-05-01)

Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
by: Andro Montoya, et al.
Published: (2019-12-01)

Neuroinflammatory Response to TNFα and IL1β Cytokines Is Accompanied by an Increase in Glycolysis in Human Astrocytes In Vitro
by: David Pamies, et al.
Published: (2021-04-01)

Pristimerin Inhibits MMP-9 Expression and Cell Migration Through Attenuating NOX/ROS-Dependent NF-κB Activation in Rat Brain Astrocytes Challenged with LPS
by: Yang CC, et al.
Published: (2020-07-01)

Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes
by: Luca eSteardo, et al.
Published: (2015-07-01)

Evidence that erythropoietin modulates neuroinflammation through differential action on neurons, astrocytes, and microglia
by: Wesley S Bond, et al.
Published: (2014-10-01)

Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy
by: Samuel C. Woodburn, et al.
Published: (2021-05-01)

Seleno-polymannuronate attenuates neuroinflammation by suppressing microglial and astrocytic activation
by: Decheng Bi, et al.
Published: (2018-12-01)

Beyond the GFAP-Astrocyte Protein Markers in the Brain
by: Agnieszka M. Jurga, et al.
Published: (2021-09-01)

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development
by: Isabella Farhy-Tselnicker, et al.
Published: (2018-05-01)

Galangin Inhibits LPS-Induced MMP-9 Expression via Suppressing Protein Kinase-Dependent AP-1 and FoxO1 Activation in Rat Brain Astrocytes
by: Yang CC, et al.
Published: (2020-11-01)

An update on reactive astrocytes in chronic pain
by: Ting Li, et al.
Published: (2019-07-01)

Targeting neuroinflammation in Alzheimer’s disease
by: Bronzuoli MR, et al.
Published: (2016-11-01)

Phagocytic Activities of Reactive Microglia and Astrocytes Associated with Prion Diseases Are Dysregulated in Opposite Directions
by: Anshuman Sinha, et al.
Published: (2021-07-01)

Different Flavors of Astrocytes: Revising the Origins of Astrocyte Diversity and Epigenetic Signatures to Understand Heterogeneity after Injury
by: Alejandro Villarreal, et al.
Published: (2021-06-01)

Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction
by: Anze Testen, et al.
Published: (2018-08-01)

BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis
by: Honglu Ding, et al.
Published: (2020-01-01)

Region-Specific Response of Astrocytes to Prion Infection
by: Natallia Makarava, et al.
Published: (2019-10-01)

Imaging and monitoring astrocytes in health and disease
by: Carole eEscartin, et al.
Published: (2014-03-01)

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling
by: Tahir Muhammad, et al.
Published: (2019-03-01)

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid
by: Ewa Kozela, et al.
Published: (2017-07-01)

Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation
by: Jae-Hong Kim, et al.
Published: (2021-03-01)

Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke
by: Fatemeh Ranjbar Taklimie, et al.
Published: (2019-03-01)

She Doesn’t Even Go Here: The Role of Inflammatory Astrocytes in CNS Disorders
by: Jacqueline Kelsey Reid, et al.
Published: (2021-09-01)

Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion
by: Alizé Proust, et al.
Published: (2017-12-01)

A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation
by: Noah Goshi, et al.
Published: (2020-05-01)

Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation
by: Jia-Hui He, et al.
Published: (2021-02-01)

Exosomal MicroRNAs Released by Activated Astrocytes as Potential Neuroinflammatory Biomarkers
by: Manoshi Gayen, et al.
Published: (2020-03-01)

Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
by: Eugene Bok, et al.
Published: (2019-01-01)

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells
by: Ana S. Falcão, et al.
Published: (2005-11-01)

Docosahexaenoic fatty acid reduces the pro‐inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation
by: Emilia Zgórzyńska, et al.
Published: (2021-01-01)

The Role of Microglia and Astrocytes in Huntington’s Disease
by: Thulani H. Palpagama, et al.
Published: (2019-10-01)

Mechanistic Insight into the Effects of Curcumin on Neuroinflammation-Driven Chronic Pain
by: Hasriadi, et al.
Published: (2021-08-01)

The degree of astrocyte activation is predictive of the incubation time to prion disease
by: Natallia Makarava, et al.
Published: (2021-05-01)

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice
by: Alexandria N. Early, et al.
Published: (2020-04-01)