Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

Abstract Background Cystic echinococcosis (CE) is a life-threatening zoonosis caused by the larval form of Echinococcus granulosus tapeworm. Our previous study showed that an approved drug pyronaridine (PND) is highly effective against CE, both in vitro and in an animal model. To identify possible t...

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Bibliographic Details
Main Authors: Yingfang Yu, Jun Li, Weisi Wang, Tian Wang, Wenjing Qi, Xueting Zheng, Lei Duan, Jiaxu Chen, Shizhu Li, Xiumin Han, Wenbao Zhang, Liping Duan
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Genomics
Subjects:
Echinococcus granulosus
pyronaridine
RNA sequencing
Protoscoleces
MAPK
Heat shock protein
Online Access:https://doi.org/10.1186/s12864-021-07875-w

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