PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma

PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma

Bibliographic Details
Main Authors: Qin Xie, Shuaishuai Chi, Yanfen Fang, Yiming Sun, Linghua Meng, Jian Ding, Yi Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00522-6
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spelling doaj-7a29c46802c4448cae7897c58da326772021-04-04T11:18:58ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-03-01611310.1038/s41392-021-00522-6PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinomaQin Xie0Shuaishuai Chi1Yanfen Fang2Yiming Sun3Linghua Meng4Jian Ding5Yi Chen6College of Pharmaceutical Sciences, Zhejiang UniversityDivision of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDivision of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDivision of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDivision of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDivision of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDivision of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Scienceshttps://doi.org/10.1038/s41392-021-00522-6
collection DOAJ
language English
format Article
sources DOAJ
author Qin Xie
Shuaishuai Chi
Yanfen Fang
Yiming Sun
Linghua Meng
Jian Ding
Yi Chen
spellingShingle Qin Xie
Shuaishuai Chi
Yanfen Fang
Yiming Sun
Linghua Meng
Jian Ding
Yi Chen
PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
Signal Transduction and Targeted Therapy
author_facet Qin Xie
Shuaishuai Chi
Yanfen Fang
Yiming Sun
Linghua Meng
Jian Ding
Yi Chen
author_sort Qin Xie
title PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
title_short PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
title_full PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
title_fullStr PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
title_full_unstemmed PI3Kα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma
title_sort pi3kα inhibitor impairs akt phosphorylation and synergizes with novel angiogenesis inhibitor al3810 in human hepatocellular carcinoma
publisher Nature Publishing Group
series Signal Transduction and Targeted Therapy
issn 2059-3635
publishDate 2021-03-01
url https://doi.org/10.1038/s41392-021-00522-6
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AT shuaishuaichi pi3kainhibitorimpairsaktphosphorylationandsynergizeswithnovelangiogenesisinhibitoral3810inhumanhepatocellularcarcinoma
AT yanfenfang pi3kainhibitorimpairsaktphosphorylationandsynergizeswithnovelangiogenesisinhibitoral3810inhumanhepatocellularcarcinoma
AT yimingsun pi3kainhibitorimpairsaktphosphorylationandsynergizeswithnovelangiogenesisinhibitoral3810inhumanhepatocellularcarcinoma
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AT jianding pi3kainhibitorimpairsaktphosphorylationandsynergizeswithnovelangiogenesisinhibitoral3810inhumanhepatocellularcarcinoma
AT yichen pi3kainhibitorimpairsaktphosphorylationandsynergizeswithnovelangiogenesisinhibitoral3810inhumanhepatocellularcarcinoma
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