Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.
The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly expo...
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doaj-7a44cf0a968b4b2b995cee4eca3300942020-11-24T21:58:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10802410.1371/journal.pone.0108024Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.Mei YangJianchang ChenJing ZhaoMei MengThe protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+ etanercept. The results demonstrated that compared to MI/R, etanercept reduced myocardial infarction area, myocardial myeloperoxidase (MPO) levels, serum creatinine kinase (CK) and lactate dehydrogenase (LDH) levels, and both serum and myocardial TNF-α production. Etanercept also markedly enhanced the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and reduced the level of malondialdehyde (MDA) in MI/R rats. In summary, our data suggested that etanercept has protective effects against MI/R injury in rats, which may be attributed to attenuating inflammation and oxidative stress.http://europepmc.org/articles/PMC4178063?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mei Yang Jianchang Chen Jing Zhao Mei Meng |
spellingShingle |
Mei Yang Jianchang Chen Jing Zhao Mei Meng Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress. PLoS ONE |
author_facet |
Mei Yang Jianchang Chen Jing Zhao Mei Meng |
author_sort |
Mei Yang |
title |
Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress. |
title_short |
Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress. |
title_full |
Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress. |
title_fullStr |
Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress. |
title_full_unstemmed |
Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress. |
title_sort |
etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+ etanercept. The results demonstrated that compared to MI/R, etanercept reduced myocardial infarction area, myocardial myeloperoxidase (MPO) levels, serum creatinine kinase (CK) and lactate dehydrogenase (LDH) levels, and both serum and myocardial TNF-α production. Etanercept also markedly enhanced the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and reduced the level of malondialdehyde (MDA) in MI/R rats. In summary, our data suggested that etanercept has protective effects against MI/R injury in rats, which may be attributed to attenuating inflammation and oxidative stress. |
url |
http://europepmc.org/articles/PMC4178063?pdf=render |
work_keys_str_mv |
AT meiyang etanerceptattenuatesmyocardialischemiareperfusioninjurybydecreasinginflammationandoxidativestress AT jianchangchen etanerceptattenuatesmyocardialischemiareperfusioninjurybydecreasinginflammationandoxidativestress AT jingzhao etanerceptattenuatesmyocardialischemiareperfusioninjurybydecreasinginflammationandoxidativestress AT meimeng etanerceptattenuatesmyocardialischemiareperfusioninjurybydecreasinginflammationandoxidativestress |
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