Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.

The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly expo...

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Main Authors: Mei Yang, Jianchang Chen, Jing Zhao, Mei Meng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4178063?pdf=render
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spelling doaj-7a44cf0a968b4b2b995cee4eca3300942020-11-24T21:58:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10802410.1371/journal.pone.0108024Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.Mei YangJianchang ChenJing ZhaoMei MengThe protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+ etanercept. The results demonstrated that compared to MI/R, etanercept reduced myocardial infarction area, myocardial myeloperoxidase (MPO) levels, serum creatinine kinase (CK) and lactate dehydrogenase (LDH) levels, and both serum and myocardial TNF-α production. Etanercept also markedly enhanced the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and reduced the level of malondialdehyde (MDA) in MI/R rats. In summary, our data suggested that etanercept has protective effects against MI/R injury in rats, which may be attributed to attenuating inflammation and oxidative stress.http://europepmc.org/articles/PMC4178063?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Mei Yang
Jianchang Chen
Jing Zhao
Mei Meng
spellingShingle Mei Yang
Jianchang Chen
Jing Zhao
Mei Meng
Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.
PLoS ONE
author_facet Mei Yang
Jianchang Chen
Jing Zhao
Mei Meng
author_sort Mei Yang
title Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.
title_short Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.
title_full Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.
title_fullStr Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.
title_full_unstemmed Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.
title_sort etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+ etanercept. The results demonstrated that compared to MI/R, etanercept reduced myocardial infarction area, myocardial myeloperoxidase (MPO) levels, serum creatinine kinase (CK) and lactate dehydrogenase (LDH) levels, and both serum and myocardial TNF-α production. Etanercept also markedly enhanced the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and reduced the level of malondialdehyde (MDA) in MI/R rats. In summary, our data suggested that etanercept has protective effects against MI/R injury in rats, which may be attributed to attenuating inflammation and oxidative stress.
url http://europepmc.org/articles/PMC4178063?pdf=render
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AT jianchangchen etanerceptattenuatesmyocardialischemiareperfusioninjurybydecreasinginflammationandoxidativestress
AT jingzhao etanerceptattenuatesmyocardialischemiareperfusioninjurybydecreasinginflammationandoxidativestress
AT meimeng etanerceptattenuatesmyocardialischemiareperfusioninjurybydecreasinginflammationandoxidativestress
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