DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation.

Bibliographic Details
Main Authors:	Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani, Michael P. Sheetz
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01805-9

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spelling	doaj-7a4d1dd252984e45a207e050a9047c962021-05-11T07:43:12ZengNature Publishing GroupNature Communications2041-17232017-12-018111510.1038/s41467-017-01805-9DNA damage causes rapid accumulation of phosphoinositides for ATR signalingYu-Hsiu Wang0Anushya Hariharan1Giulia Bastianello2Yusuke Toyama3G. V. Shivashankar4Marco Foiani5Michael P. Sheetz6Mechanobiology Institute, National University of SingaporeMechanobiology Institute, National University of SingaporeIFOM, the FIRC Institute of Molecular Oncology, Via AdamelloMechanobiology Institute, National University of SingaporeMechanobiology Institute, National University of SingaporeIFOM, the FIRC Institute of Molecular Oncology, Via AdamelloMechanobiology Institute, National University of SingaporePhosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation.https://doi.org/10.1038/s41467-017-01805-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yu-Hsiu Wang Anushya Hariharan Giulia Bastianello Yusuke Toyama G. V. Shivashankar Marco Foiani Michael P. Sheetz
spellingShingle	Yu-Hsiu Wang Anushya Hariharan Giulia Bastianello Yusuke Toyama G. V. Shivashankar Marco Foiani Michael P. Sheetz DNA damage causes rapid accumulation of phosphoinositides for ATR signaling Nature Communications
author_facet	Yu-Hsiu Wang Anushya Hariharan Giulia Bastianello Yusuke Toyama G. V. Shivashankar Marco Foiani Michael P. Sheetz
author_sort	Yu-Hsiu Wang
title	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_short	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_full	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_fullStr	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_full_unstemmed	DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
title_sort	dna damage causes rapid accumulation of phosphoinositides for atr signaling
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR recruitment and subsequent Chk1 activation.
url	https://doi.org/10.1038/s41467-017-01805-9
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DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

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