PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer.
PFKFB3 (6-phosphofructo-2-kinase) synthesizes fructose 2,6-bisphosphate (F2,6P2), which is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), the rate-limiting enzyme of glycolysis. Overexpression of the PFKFB3 enzyme leads to high glycolytic metabolism, which is required for cancer cells...
Main Authors: | Wei Zhu, Liang Ye, Jianzhao Zhang, Pengfei Yu, Hongbo Wang, Zuguang Ye, Jingwei Tian |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5036843?pdf=render |
Similar Items
-
The influence of PFK-II overexpression on neuroblastoma patients’ survival may be dependent on the particular isoenzyme expressed, PFKFB3 or PFKFB4
by: Sonia E. Trojan, et al.
Published: (2019-11-01) -
Involvement of PFKFB3/iPFK2 in the Effects of Leucine and n-3 PUFA in Adipocytes
by: Halim, Vera
Published: (2012) -
Expression characterization of PFK-liver, PFK-muscle, and PFK-brain RNA isoforms in murine preimplantation embryos using RT-PCR
by: Henry, Jeff
Published: (2011) -
CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2
by: Qu J, et al.
Published: (2020-09-01) -
CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2 [Corrigendum]
by: Qu J, et al.
Published: (2021-01-01)