Adjuvant-Associated Peripheral Blood mRNA Profiles and Kinetics Induced by the Adjuvanted Recombinant Protein Candidate Tuberculosis Vaccine M72/AS01 in Bacillus Calmette–Guérin-Vaccinated Adults

Adjuvant-Associated Peripheral Blood mRNA Profiles and Kinetics Induced by the Adjuvanted Recombinant Protein Candidate Tuberculosis Vaccine M72/AS01 in Bacillus Calmette–Guérin-Vaccinated Adults

Systems biology has the potential to identify gene signatures associated with vaccine immunogenicity and protective efficacy. The main objective of this study was to identify optimal postvaccination time points for evaluating peripheral blood RNA expression profiles in relation to vaccine immunogeni...

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Bibliographic Details
Main Authors: Robert A. van den Berg, Laurane De Mot, Geert Leroux-Roels, Viviane Bechtold, Frédéric Clement, Margherita Coccia, Erik Jongert, Thomas G. Evans, Paul Gillard, Robbert G. van der Most
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
vaccine
adjuvant system
innate immunity
interferon
transcriptome
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00564/full

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