Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India
The recognition of DF (DHF Dengue Hemorrhagic Fever) is very complicated due to occurrence of a wide spectrum of clinical signs and symptoms during acute phase of illness. Moreover, presence of four serotypes further complicates the prognosis. To investigate the predictors of disease severity and el...
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doaj-7a646d65405048ffaad4bfdf414589532020-11-25T03:04:44ZengElsevierBrazilian Journal of Infectious Diseases1413-86702010-03-01142141146Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from IndiaRajni Kumaria0Correspondence to:Singapore-MIT Alliance for Research and Technology, National University of Singapore, Singapore. Phone: 65 82282240.; Postdoctoral Associate – Singapore-MIT Alliance for Research and Technology, National University of Singapore, SingaporeThe recognition of DF (DHF Dengue Hemorrhagic Fever) is very complicated due to occurrence of a wide spectrum of clinical signs and symptoms during acute phase of illness. Moreover, presence of four serotypes further complicates the prognosis. To investigate the predictors of disease severity and elucidate the prognostic markers among four dengue serotypes, this study was conducted on 320 inpatients having acute febrile illness clinically suspected as DI, over a period of five years. Dengue serotypes were confirmed by multiplex reverse transcriptase (RT)-PCR. Eighty patients were positive for DI with presence of Den-1, Den-2, Den-3, and Den-4 in 8, 35, 27 and 10 patients, respectively. The severe clinical manifestations, abdominal pain and hepatomegaly, were comparatively higher in Den-2 patients. Liver aminotransferases levels were also higher in Den-2 patients (app. 5 fold). This study clearly indicates the hyperendemicity of all dengue serotypes. Nucleotide sequencing of Envelope region revealed that the presently emerged Den-3 belongs to type III, having high homology with genotype responsible for number of outbreaks in 1980s. The re-emergence of this deadly type can be suspected to cause more outbreaks in future and is a matter of great concern. Keywords: Dengue fever, dengue infection, serotype, clinical spectra, liver transaminasehttp://www.sciencedirect.com/science/article/pii/S1413867010700271 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rajni Kumaria |
spellingShingle |
Rajni Kumaria Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India Brazilian Journal of Infectious Diseases |
author_facet |
Rajni Kumaria |
author_sort |
Rajni Kumaria |
title |
Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India |
title_short |
Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India |
title_full |
Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India |
title_fullStr |
Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India |
title_full_unstemmed |
Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India |
title_sort |
correlation of disease spectrum among four dengue serotypes: a five years hospital based study from india |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2010-03-01 |
description |
The recognition of DF (DHF Dengue Hemorrhagic Fever) is very complicated due to occurrence of a wide spectrum of clinical signs and symptoms during acute phase of illness. Moreover, presence of four serotypes further complicates the prognosis. To investigate the predictors of disease severity and elucidate the prognostic markers among four dengue serotypes, this study was conducted on 320 inpatients having acute febrile illness clinically suspected as DI, over a period of five years. Dengue serotypes were confirmed by multiplex reverse transcriptase (RT)-PCR. Eighty patients were positive for DI with presence of Den-1, Den-2, Den-3, and Den-4 in 8, 35, 27 and 10 patients, respectively. The severe clinical manifestations, abdominal pain and hepatomegaly, were comparatively higher in Den-2 patients. Liver aminotransferases levels were also higher in Den-2 patients (app. 5 fold). This study clearly indicates the hyperendemicity of all dengue serotypes. Nucleotide sequencing of Envelope region revealed that the presently emerged Den-3 belongs to type III, having high homology with genotype responsible for number of outbreaks in 1980s. The re-emergence of this deadly type can be suspected to cause more outbreaks in future and is a matter of great concern. Keywords: Dengue fever, dengue infection, serotype, clinical spectra, liver transaminase |
url |
http://www.sciencedirect.com/science/article/pii/S1413867010700271 |
work_keys_str_mv |
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