Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis
DNA methylation primarily occurs on CpG dinucleotides and plays an important role in transcriptional regulations during tissue development and cell differentiation. Over 25% of CpG dinucleotides in the human genome reside within Alu elements, the most abundant human repeats. The methylation of Alu e...
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Online Access: | http://dx.doi.org/10.1155/2014/784706 |
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doaj-7a646f6a8e35405c9872ea24d570b13e2020-11-24T22:47:16ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/784706784706Dynamic Alu Methylation during Normal Development, Aging, and TumorigenesisYanting Luo0Xuemei Lu1Hehuang Xie2Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, ChinaBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, ChinaBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, ChinaDNA methylation primarily occurs on CpG dinucleotides and plays an important role in transcriptional regulations during tissue development and cell differentiation. Over 25% of CpG dinucleotides in the human genome reside within Alu elements, the most abundant human repeats. The methylation of Alu elements is an important mechanism to suppress Alu transcription and subsequent retrotransposition. Decades of studies revealed that Alu methylation is highly dynamic during early development and aging. Recently, many environmental factors were shown to have a great impact on Alu methylation. In addition, aberrant Alu methylation has been documented to be an early event in many tumors and Alu methylation levels have been associated with tumor aggressiveness. The assessment of the Alu methylation has become an important approach for early diagnosis and/or prognosis of cancer. This review focuses on the dynamic Alu methylation during development, aging, and tumor genesis. The cause and consequence of Alu methylation changes will be discussed.http://dx.doi.org/10.1155/2014/784706 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanting Luo Xuemei Lu Hehuang Xie |
spellingShingle |
Yanting Luo Xuemei Lu Hehuang Xie Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis BioMed Research International |
author_facet |
Yanting Luo Xuemei Lu Hehuang Xie |
author_sort |
Yanting Luo |
title |
Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis |
title_short |
Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis |
title_full |
Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis |
title_fullStr |
Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis |
title_full_unstemmed |
Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis |
title_sort |
dynamic alu methylation during normal development, aging, and tumorigenesis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
DNA methylation primarily occurs on CpG dinucleotides and plays an important role in transcriptional regulations during tissue development and cell differentiation. Over 25% of CpG dinucleotides in the human genome reside within Alu elements, the most abundant human repeats. The methylation of Alu elements is an important mechanism to suppress Alu transcription and subsequent retrotransposition. Decades of studies revealed that Alu methylation is highly dynamic during early development and aging. Recently, many environmental factors were shown to have a great impact on Alu methylation. In addition, aberrant Alu methylation has been documented to be an early event in many tumors and Alu methylation levels have been associated with tumor aggressiveness. The assessment of the Alu methylation has become an important approach for early diagnosis and/or prognosis of cancer. This review focuses on the dynamic Alu methylation during development, aging, and tumor genesis. The cause and consequence of Alu methylation changes will be discussed. |
url |
http://dx.doi.org/10.1155/2014/784706 |
work_keys_str_mv |
AT yantingluo dynamicalumethylationduringnormaldevelopmentagingandtumorigenesis AT xuemeilu dynamicalumethylationduringnormaldevelopmentagingandtumorigenesis AT hehuangxie dynamicalumethylationduringnormaldevelopmentagingandtumorigenesis |
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1725682284424593408 |