The Role of Magnetic Resonance Spectroscopy Imaging Parameters to Predict Early Biochemical Recurrence after Radical Prostatectomy
To evaluate the role of magnetic resonance spectroscopy imaging (MRSI) parameters to predict early biochemical recurrence (BCR) after radical prostatectomy (RP) in patients with non-metastatic prostate cancer (PCa). Between November 2010 and March 2012, 60 consecutive patients with clinically non-me...
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doaj-7a6804cfabf943b0bdcfb341f538b3ae2020-11-25T00:09:05ZengKarolinum PressPrague Medical Report1214-69942336-29362019-10-011202748310.14712/23362936.2019.128870The Role of Magnetic Resonance Spectroscopy Imaging Parameters to Predict Early Biochemical Recurrence after Radical ProstatectomyMehdi Kardoust PariziAli RaziSoheil AlizadehAmir KasaeianTo evaluate the role of magnetic resonance spectroscopy imaging (MRSI) parameters to predict early biochemical recurrence (BCR) after radical prostatectomy (RP) in patients with non-metastatic prostate cancer (PCa). Between November 2010 and March 2012, 60 consecutive patients with clinically non-metastatic biopsy confirmed PCa underwent RP after MRSI assessment in a prospective study. Demographic, clinicopathological, magnetic resonance imaging (MRI) staging, MRSI parameters, and postoperative serum prostate-specific antigen were recorded. The univariate and multivariate Cox regression analyses were used to assess the association between potential prognosticators and early BCR (BCR less than 12 months after RP). In univariate Cox regression, preoperative serum PSA (prostate-specific antigen) (HR – hazard ratio = 1.016, p=0.003), surgical Gleason score > 7 (HR = 5.034, p=0.006) and MRSI risk score (HR = 4.061, p=0.0001); and in multivariate model, preoperative serum PSA (HR = 1.012; p=0.046), surgical GS > 7 (HR = 4.196; p=0.017) and MRSI risk score (HR = 3.256; p=0.013) were associated with early BCR. The greatest AUC (area under the curve) was related to MRSI risk score (AUC = 0.733) and the AUC of the multivariate model was 0.776. MRI/MRSI parameters specially MRSI risk score might be acceptable predictors of early BCR. These parameters can improve the accuracy of predictive nomograms to assess the risk of BCR after RP.https://pmr.lf1.cuni.cz/120/2/0074/ProstatectomyRecurrenceMR spectroscopyProstate cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehdi Kardoust Parizi Ali Razi Soheil Alizadeh Amir Kasaeian |
spellingShingle |
Mehdi Kardoust Parizi Ali Razi Soheil Alizadeh Amir Kasaeian The Role of Magnetic Resonance Spectroscopy Imaging Parameters to Predict Early Biochemical Recurrence after Radical Prostatectomy Prague Medical Report Prostatectomy Recurrence MR spectroscopy Prostate cancer |
author_facet |
Mehdi Kardoust Parizi Ali Razi Soheil Alizadeh Amir Kasaeian |
author_sort |
Mehdi Kardoust Parizi |
title |
The Role of Magnetic Resonance Spectroscopy Imaging Parameters to Predict Early Biochemical Recurrence after Radical Prostatectomy |
title_short |
The Role of Magnetic Resonance Spectroscopy Imaging Parameters to Predict Early Biochemical Recurrence after Radical Prostatectomy |
title_full |
The Role of Magnetic Resonance Spectroscopy Imaging Parameters to Predict Early Biochemical Recurrence after Radical Prostatectomy |
title_fullStr |
The Role of Magnetic Resonance Spectroscopy Imaging Parameters to Predict Early Biochemical Recurrence after Radical Prostatectomy |
title_full_unstemmed |
The Role of Magnetic Resonance Spectroscopy Imaging Parameters to Predict Early Biochemical Recurrence after Radical Prostatectomy |
title_sort |
role of magnetic resonance spectroscopy imaging parameters to predict early biochemical recurrence after radical prostatectomy |
publisher |
Karolinum Press |
series |
Prague Medical Report |
issn |
1214-6994 2336-2936 |
publishDate |
2019-10-01 |
description |
To evaluate the role of magnetic resonance spectroscopy imaging (MRSI) parameters to predict early biochemical recurrence (BCR) after radical prostatectomy (RP) in patients with non-metastatic prostate cancer (PCa). Between November 2010 and March 2012, 60 consecutive patients with clinically non-metastatic biopsy confirmed PCa underwent RP after MRSI assessment in a prospective study. Demographic, clinicopathological, magnetic resonance imaging (MRI) staging, MRSI parameters, and postoperative serum prostate-specific antigen were recorded. The univariate and multivariate Cox regression analyses were used to assess the association between potential prognosticators and early BCR (BCR less than 12 months after RP). In univariate Cox regression, preoperative serum PSA (prostate-specific antigen) (HR – hazard ratio = 1.016, p=0.003), surgical Gleason score > 7 (HR = 5.034, p=0.006) and MRSI risk score (HR = 4.061, p=0.0001); and in multivariate model, preoperative serum PSA (HR = 1.012; p=0.046), surgical GS > 7 (HR = 4.196; p=0.017) and MRSI risk score (HR = 3.256; p=0.013) were associated with early BCR. The greatest AUC (area under the curve) was related to MRSI risk score (AUC = 0.733) and the AUC of the multivariate model was 0.776. MRI/MRSI parameters specially MRSI risk score might be acceptable predictors of early BCR. These parameters can improve the accuracy of predictive nomograms to assess the risk of BCR after RP. |
topic |
Prostatectomy Recurrence MR spectroscopy Prostate cancer |
url |
https://pmr.lf1.cuni.cz/120/2/0074/ |
work_keys_str_mv |
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