Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ

Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ

The human iPSC cell line ZJUCHi001-A was established from renal epithelial cells present in urine (urinary cells) harvested from a 2-year-old Charcot-Marie-Tooth disease type 1B (CMT1B) patient carrying point mutation in MPZ (c.292C>T). Urinary cells were reprogrammed by retrovirus vectors contai...

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Main Authors: Jiake Xu, Yanpeng Wang, Jing He, Weichun Xia, Yan Zou, Wencong Ruan, Qi Lou, Ying Li, Haifeng Li, Wei Chen
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506119300376
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spelling doaj-7a6ae1a4e64b49c7b3a87c71d36569b72020-11-24T23:06:44ZengElsevierStem Cell Research1873-50612019-03-0135Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZJiake Xu0Yanpeng Wang1Jing He2Weichun Xia3Yan Zou4Wencong Ruan5Qi Lou6Ying Li7Haifeng Li8Wei Chen9The Children's Hospital Affiliated, Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou 310052, China; Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310020, ChinaDepartment of Gynecology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, ChinaThe Children's Hospital Affiliated, Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou 310052, China; Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310020, ChinaThe Children's Hospital Affiliated, Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou 310052, China; Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310020, ChinaZhejiang Center for Disease Control and Prevention, ChinaThe Pediatric Rehabilitation Department, The Children's Hospital, School of Medicine, Zhejiang University, ChinaExperimental Animal Center, Zhejiang Academy of Medical Sciences, Hangzhou 310013, ChinaThe Children's Hospital Affiliated, Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou 310052, China; Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310020, ChinaThe Pediatric Rehabilitation Department, The Children's Hospital, School of Medicine, Zhejiang University, China; Corresponding author.The Children's Hospital Affiliated, Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou 310052, China; Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310020, China; Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, School of Medicine, Zhejiang University, Hangzhou 310058, China; Corresponding author at: The Children's Hospital Affiliated, Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou 310052, China.The human iPSC cell line ZJUCHi001-A was established from renal epithelial cells present in urine (urinary cells) harvested from a 2-year-old Charcot-Marie-Tooth disease type 1B (CMT1B) patient carrying point mutation in MPZ (c.292C>T). Urinary cells were reprogrammed by retrovirus vectors containing reprogramming factors: OCT4, SOX2, KLF4 and c-MYC. The pluripotency, capacity of differentiation into 3 germ layers, silence of reprogramming factors and normal karyotype for this cell line were all confirmed in this study.http://www.sciencedirect.com/science/article/pii/S1873506119300376
collection DOAJ
language English
format Article
sources DOAJ
author Jiake Xu
Yanpeng Wang
Jing He
Weichun Xia
Yan Zou
Wencong Ruan
Qi Lou
Ying Li
Haifeng Li
Wei Chen
spellingShingle Jiake Xu
Yanpeng Wang
Jing He
Weichun Xia
Yan Zou
Wencong Ruan
Qi Lou
Ying Li
Haifeng Li
Wei Chen
Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ
Stem Cell Research
author_facet Jiake Xu
Yanpeng Wang
Jing He
Weichun Xia
Yan Zou
Wencong Ruan
Qi Lou
Ying Li
Haifeng Li
Wei Chen
author_sort Jiake Xu
title Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ
title_short Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ
title_full Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ
title_fullStr Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ
title_full_unstemmed Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ
title_sort generation of a human charcot-marie-tooth disease type 1b (cmt1b) ipsc line, zjuchi001-a, with a mutation of c.292c>t in mpz
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2019-03-01
description The human iPSC cell line ZJUCHi001-A was established from renal epithelial cells present in urine (urinary cells) harvested from a 2-year-old Charcot-Marie-Tooth disease type 1B (CMT1B) patient carrying point mutation in MPZ (c.292C>T). Urinary cells were reprogrammed by retrovirus vectors containing reprogramming factors: OCT4, SOX2, KLF4 and c-MYC. The pluripotency, capacity of differentiation into 3 germ layers, silence of reprogramming factors and normal karyotype for this cell line were all confirmed in this study.
url http://www.sciencedirect.com/science/article/pii/S1873506119300376
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