Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
Abstract Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof of principle for a novel two-pronged modality referred to as Synergistic Immuno Photothermal Nanotherapy...
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2017-08-01
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doaj-7a7a54c93aa543e3b9bbc73ed1387d7a2020-12-08T01:03:58ZengNature Publishing GroupScientific Reports2045-23222017-08-01711610.1038/s41598-017-09116-1Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic CancersYang Liu0Paolo Maccarini1Gregory M. Palmer2Wiguins Etienne3Yulin Zhao4Chen-Ting Lee5Xiumei Ma6Brant A. Inman7Tuan Vo-Dinh8Department of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Radiation Oncology, Duke University Medical CenterDepartment of Surgery, Duke University Medical CenterDepartment of Radiation Oncology, Duke University Medical CenterDepartment of Radiation Oncology, Duke University Medical CenterDepartment of Radiation Oncology, Duke University Medical CenterDepartment of Surgery, Duke University Medical CenterDepartment of Biomedical Engineering, Duke UniversityAbstract Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof of principle for a novel two-pronged modality referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) having the potential to safely eradicate both primary tumors and distant metastatic foci. Using a combination of immune-checkpoint inhibition and plasmonic gold nanostar (GNS)–mediated photothermal therapy, we were able to achieve complete eradication of primary treated tumors and distant untreated tumors in some mice implanted with the MB49 bladder cancer cells. Delayed rechallenge with MB49 cancer cells injection in mice that appeared cured by SYMPHONY did not lead to new tumor formation after 60 days observation, indicating that SYMPHONY treatment induced effective long-lasting immunity against MB49 cancer cells.https://doi.org/10.1038/s41598-017-09116-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Liu Paolo Maccarini Gregory M. Palmer Wiguins Etienne Yulin Zhao Chen-Ting Lee Xiumei Ma Brant A. Inman Tuan Vo-Dinh |
spellingShingle |
Yang Liu Paolo Maccarini Gregory M. Palmer Wiguins Etienne Yulin Zhao Chen-Ting Lee Xiumei Ma Brant A. Inman Tuan Vo-Dinh Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers Scientific Reports |
author_facet |
Yang Liu Paolo Maccarini Gregory M. Palmer Wiguins Etienne Yulin Zhao Chen-Ting Lee Xiumei Ma Brant A. Inman Tuan Vo-Dinh |
author_sort |
Yang Liu |
title |
Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers |
title_short |
Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers |
title_full |
Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers |
title_fullStr |
Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers |
title_full_unstemmed |
Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers |
title_sort |
synergistic immuno photothermal nanotherapy (symphony) for the treatment of unresectable and metastatic cancers |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-08-01 |
description |
Abstract Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof of principle for a novel two-pronged modality referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) having the potential to safely eradicate both primary tumors and distant metastatic foci. Using a combination of immune-checkpoint inhibition and plasmonic gold nanostar (GNS)–mediated photothermal therapy, we were able to achieve complete eradication of primary treated tumors and distant untreated tumors in some mice implanted with the MB49 bladder cancer cells. Delayed rechallenge with MB49 cancer cells injection in mice that appeared cured by SYMPHONY did not lead to new tumor formation after 60 days observation, indicating that SYMPHONY treatment induced effective long-lasting immunity against MB49 cancer cells. |
url |
https://doi.org/10.1038/s41598-017-09116-1 |
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