Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis
To evaluate the relationship between the aryl hydrocarbon receptor (AHR) rs2066853 gene polymorphism and the risk of male infertility. PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant case–control studies up to 31 July 2019. Odds ratio (...
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Online Access: | http://dx.doi.org/10.1080/0886022X.2019.1673775 |
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doaj-7a834dc6f03b404d8a029ec88ed3c8252021-06-02T08:05:29ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492019-01-0141198799410.1080/0886022X.2019.16737751673775Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysisZheng-Ju Ren0DeHong Cao1Peng-Wei Ren2Bo Yang3Dong-Liang Lu4Jian Liao5Sheng-Zhuo Liu6Lu-Cheng Yang7Zhu-Feng Peng8Liang-Ren Liu9Qiang Dong10West China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityWest China Hospital, Sichuan UniversityTo evaluate the relationship between the aryl hydrocarbon receptor (AHR) rs2066853 gene polymorphism and the risk of male infertility. PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant case–control studies up to 31 July 2019. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of associations. Finally, seven case–control studies involving 1247 cases and 1762 controls were included in this meta-analysis. The pooled results showed that there was no significant association between AHR rs2066853 gene polymorphism and male infertility risk (A vs. G: OR = 1.08, 95% CI = 0.83–1.39; AA vs. GG: OR = 1.16, 95% CI = 0.65–2.04; AA vs. GA + GG: OR = 1.17, 95% CI = 0.66–2.07; AA + GA vs. GG: OR = 0.99, 95% CI = 0.85–1.15). Subgroup analysis by ethnicity showed the same result. However, significant association was found between AHR rs2066853 gene polymorphism and male infertility risk in oligoasthenotspermia (A vs. G: OR = 2.52, 95% CI = 1.72–3.70). In conclusion, our meta-analysis indicated that AHR rs2066853 gene polymorphism might be associated with an increased susceptibility to oligoasthenotspermia.http://dx.doi.org/10.1080/0886022X.2019.1673775aryl hydrocarbon receptorahr genepolymorphismmale infertilitymeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zheng-Ju Ren DeHong Cao Peng-Wei Ren Bo Yang Dong-Liang Lu Jian Liao Sheng-Zhuo Liu Lu-Cheng Yang Zhu-Feng Peng Liang-Ren Liu Qiang Dong |
spellingShingle |
Zheng-Ju Ren DeHong Cao Peng-Wei Ren Bo Yang Dong-Liang Lu Jian Liao Sheng-Zhuo Liu Lu-Cheng Yang Zhu-Feng Peng Liang-Ren Liu Qiang Dong Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis Renal Failure aryl hydrocarbon receptor ahr gene polymorphism male infertility meta-analysis |
author_facet |
Zheng-Ju Ren DeHong Cao Peng-Wei Ren Bo Yang Dong-Liang Lu Jian Liao Sheng-Zhuo Liu Lu-Cheng Yang Zhu-Feng Peng Liang-Ren Liu Qiang Dong |
author_sort |
Zheng-Ju Ren |
title |
Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis |
title_short |
Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis |
title_full |
Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis |
title_fullStr |
Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis |
title_full_unstemmed |
Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis |
title_sort |
aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis |
publisher |
Taylor & Francis Group |
series |
Renal Failure |
issn |
0886-022X 1525-6049 |
publishDate |
2019-01-01 |
description |
To evaluate the relationship between the aryl hydrocarbon receptor (AHR) rs2066853 gene polymorphism and the risk of male infertility. PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant case–control studies up to 31 July 2019. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of associations. Finally, seven case–control studies involving 1247 cases and 1762 controls were included in this meta-analysis. The pooled results showed that there was no significant association between AHR rs2066853 gene polymorphism and male infertility risk (A vs. G: OR = 1.08, 95% CI = 0.83–1.39; AA vs. GG: OR = 1.16, 95% CI = 0.65–2.04; AA vs. GA + GG: OR = 1.17, 95% CI = 0.66–2.07; AA + GA vs. GG: OR = 0.99, 95% CI = 0.85–1.15). Subgroup analysis by ethnicity showed the same result. However, significant association was found between AHR rs2066853 gene polymorphism and male infertility risk in oligoasthenotspermia (A vs. G: OR = 2.52, 95% CI = 1.72–3.70). In conclusion, our meta-analysis indicated that AHR rs2066853 gene polymorphism might be associated with an increased susceptibility to oligoasthenotspermia. |
topic |
aryl hydrocarbon receptor ahr gene polymorphism male infertility meta-analysis |
url |
http://dx.doi.org/10.1080/0886022X.2019.1673775 |
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