Methotrexate improves the anti-arthritic effects of Paeoniflorin-6'-O-benzene sulfonate by enhancing its pharmacokinetic properties in adjuvant-induced arthritis rats

Methotrexate improves the anti-arthritic effects of Paeoniflorin-6'-O-benzene sulfonate by enhancing its pharmacokinetic properties in adjuvant-induced arthritis rats

Paeoniflorin-6'-O-benzene sulfonate (CP-25), is a novel derivative of paeoniflorin (Pae) with improved anti-arthritic effects. The aim of this study was to evaluate the therapeutic effects and pharmacokinetics of CP-25 when co-administered with MTX in adjuvant-induced arthritis (AA) rats. AA ra...

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Bibliographic Details
Main Authors:	James Asenso, Jun Yu, Feng Xiao, Mingyi Zhao, Jian Wang, Yijin Wu, Chun Wang, Wei Wei
Format:	Article
Language:	English
Published:	Elsevier 2019-04-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Arthritis Co-administration Methotrexate Paeoniflorin-6'-O-benzene sulfonate Pharmacokinetics
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332218375498

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