Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention...

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Bibliographic Details
Main Authors: Yang Bai, Miao Li, Yanmei Zhou, Lei Ma, Qian Qiao, Wanling Hu, Wei Li, Zachary Patrick Wills, Wen-Biao Gan
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Dendritic calcium activity
Two-photon imaging
APPswe/PS1dE9
Soluble Aβ oligomers
Synaptic depotentiation
Online Access:http://link.springer.com/article/10.1186/s13024-017-0228-2

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