Epigenetic Regulations in Neural Stem Cells and Neurological Diseases
Among the regulatory mechanisms of the renewal and differentiation of neural stem cells, recent evidences support that epigenetic modifications such as DNA methylation, histone modification, and noncoding RNAs play critical roles in the regulation on the proliferation and differentiation of neural s...
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2018-01-01
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Series: | Stem Cells International |
Online Access: | http://dx.doi.org/10.1155/2018/6087143 |
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doaj-7a9339cfb52e410892246fde37d17def2020-11-24T23:12:22ZengHindawi LimitedStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/60871436087143Epigenetic Regulations in Neural Stem Cells and Neurological DiseasesHang Zhou0Bin Wang1Hao Sun2Xingshun Xu3Yongxiang Wang4Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience, Soochow University, Suzhou, ChinaDepartment of Orthopedics, Clinical Medical School, Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou 225001, ChinaDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, Clinical Medical School, Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou 225001, ChinaAmong the regulatory mechanisms of the renewal and differentiation of neural stem cells, recent evidences support that epigenetic modifications such as DNA methylation, histone modification, and noncoding RNAs play critical roles in the regulation on the proliferation and differentiation of neural stem cells. In this review, we discussed recent advances of DNA modifications on the regulative mechanisms of neural stem cells. Among these epigenetic modifications, DNA 5-hydroxymethylcytosine (5hmC) modification is emerging as an important modulator on the proliferation and differentiation of neural stem cells. At the same time, Ten-eleven translocation (Tet) methylcytosine dioxygenases, the rate-limiting enzyme for the 5-hydroxymethylation reaction from 5-methylcytosine to 5-hydroxymethylcytosine, play a critical role in the tumorigenesis and the proliferation and differentiation of stem cells. The functions of 5hmC and TET proteins on neural stem cells and their roles in neurological diseases are discussed.http://dx.doi.org/10.1155/2018/6087143 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hang Zhou Bin Wang Hao Sun Xingshun Xu Yongxiang Wang |
spellingShingle |
Hang Zhou Bin Wang Hao Sun Xingshun Xu Yongxiang Wang Epigenetic Regulations in Neural Stem Cells and Neurological Diseases Stem Cells International |
author_facet |
Hang Zhou Bin Wang Hao Sun Xingshun Xu Yongxiang Wang |
author_sort |
Hang Zhou |
title |
Epigenetic Regulations in Neural Stem Cells and Neurological Diseases |
title_short |
Epigenetic Regulations in Neural Stem Cells and Neurological Diseases |
title_full |
Epigenetic Regulations in Neural Stem Cells and Neurological Diseases |
title_fullStr |
Epigenetic Regulations in Neural Stem Cells and Neurological Diseases |
title_full_unstemmed |
Epigenetic Regulations in Neural Stem Cells and Neurological Diseases |
title_sort |
epigenetic regulations in neural stem cells and neurological diseases |
publisher |
Hindawi Limited |
series |
Stem Cells International |
issn |
1687-966X 1687-9678 |
publishDate |
2018-01-01 |
description |
Among the regulatory mechanisms of the renewal and differentiation of neural stem cells, recent evidences support that epigenetic modifications such as DNA methylation, histone modification, and noncoding RNAs play critical roles in the regulation on the proliferation and differentiation of neural stem cells. In this review, we discussed recent advances of DNA modifications on the regulative mechanisms of neural stem cells. Among these epigenetic modifications, DNA 5-hydroxymethylcytosine (5hmC) modification is emerging as an important modulator on the proliferation and differentiation of neural stem cells. At the same time, Ten-eleven translocation (Tet) methylcytosine dioxygenases, the rate-limiting enzyme for the 5-hydroxymethylation reaction from 5-methylcytosine to 5-hydroxymethylcytosine, play a critical role in the tumorigenesis and the proliferation and differentiation of stem cells. The functions of 5hmC and TET proteins on neural stem cells and their roles in neurological diseases are discussed. |
url |
http://dx.doi.org/10.1155/2018/6087143 |
work_keys_str_mv |
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