Prognostic value of Onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitors
Abstract Background Immunoinflammatory and nutritional markers, such as the peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and Onodera’s prognostic nutritional index (OPNI), have gained considerable attention and have been preliminarily revealed as prognost...
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doaj-7a9938f351be4b2d8608ded82dacb14f2021-08-08T11:36:02ZengBMCWorld Journal of Surgical Oncology1477-78192021-08-0119111110.1186/s12957-021-02345-9Prognostic value of Onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitorsFeng Wang0Tingting Tao1Heng Yu2Yingying Xu3Zhi Yang4Xuefeng Xia5Meng Wang6Liang Zong7Wenxian Guan8Department of General Surgery, Drum Tower Clinical Medical College of Nanjing Medical UniversityDepartment of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of General Surgery, Drum Tower Clinical Medical College of Nanjing Medical UniversityDepartment of General Surgery, Yizhen People’s Hospital, Clinical Medical College, Yangzhou UniversityDepartment of General Surgery, Drum Tower Clinical Medical College of Nanjing Medical UniversityDepartment of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Gastrointestinal Surgery, Changzhi People’s Hospital, The Affiliated Hospital of Changzhi Medical CollegeDepartment of General Surgery, Drum Tower Clinical Medical College of Nanjing Medical UniversityAbstract Background Immunoinflammatory and nutritional markers, such as the peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and Onodera’s prognostic nutritional index (OPNI), have gained considerable attention and have been preliminarily revealed as prognostic markers of gastrointestinal stromal tumors (GISTs). Methods In this study, we first investigated the prognostic value of OPNI in GISTs treated with or without TKIs based on the propensity score matching (PSM) method. All of the patients had received surgical resection for primary GIST, and data from 2010 to 2018 were initially and retrospectively identified from our gastrointestinal center. Recurrence-free survival (RFS) was calculated by the Kaplan–Meier method and compared by the log-rank test. Results The patients were divided into groups treated and not treated with TKIs, and we used the propensity score matching method to homogenize their baseline data. Multivariate Cox proportional hazard regression models were applied to identify associations with outcome variables. A total of 563 GISTs were initially chosen, and 280 of them were included for analysis under the inclusion criteria. After PSM, there were 200 patients included. Multivariate analyses identified OPNI as an independent prognostic marker that was associated with primary site, tumor size, mitotic index, tumor rupture, necrosis, and modified NIH risk classification. Low OPNI (< 42.6; HR 0.409; P < 0.001) was associated with worse RFS. Conclusions Preoperative OPNI is a novel and useful prognostic marker for GISTs both treated and not treated with TKIs. Higher NLR and PLR have negative effects on RFS.https://doi.org/10.1186/s12957-021-02345-9Gastrointestinal stromal tumorNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioOnodera’s prognostic nutritional indexPropensity score matchingPrognostic marker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feng Wang Tingting Tao Heng Yu Yingying Xu Zhi Yang Xuefeng Xia Meng Wang Liang Zong Wenxian Guan |
spellingShingle |
Feng Wang Tingting Tao Heng Yu Yingying Xu Zhi Yang Xuefeng Xia Meng Wang Liang Zong Wenxian Guan Prognostic value of Onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitors World Journal of Surgical Oncology Gastrointestinal stromal tumor Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Onodera’s prognostic nutritional index Propensity score matching Prognostic marker |
author_facet |
Feng Wang Tingting Tao Heng Yu Yingying Xu Zhi Yang Xuefeng Xia Meng Wang Liang Zong Wenxian Guan |
author_sort |
Feng Wang |
title |
Prognostic value of Onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitors |
title_short |
Prognostic value of Onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitors |
title_full |
Prognostic value of Onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitors |
title_fullStr |
Prognostic value of Onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitors |
title_full_unstemmed |
Prognostic value of Onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitors |
title_sort |
prognostic value of onodera’s nutritional index for intermediate- and high-risk gastrointestinal stromal tumors treated with or without tyrosine kinase inhibitors |
publisher |
BMC |
series |
World Journal of Surgical Oncology |
issn |
1477-7819 |
publishDate |
2021-08-01 |
description |
Abstract Background Immunoinflammatory and nutritional markers, such as the peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and Onodera’s prognostic nutritional index (OPNI), have gained considerable attention and have been preliminarily revealed as prognostic markers of gastrointestinal stromal tumors (GISTs). Methods In this study, we first investigated the prognostic value of OPNI in GISTs treated with or without TKIs based on the propensity score matching (PSM) method. All of the patients had received surgical resection for primary GIST, and data from 2010 to 2018 were initially and retrospectively identified from our gastrointestinal center. Recurrence-free survival (RFS) was calculated by the Kaplan–Meier method and compared by the log-rank test. Results The patients were divided into groups treated and not treated with TKIs, and we used the propensity score matching method to homogenize their baseline data. Multivariate Cox proportional hazard regression models were applied to identify associations with outcome variables. A total of 563 GISTs were initially chosen, and 280 of them were included for analysis under the inclusion criteria. After PSM, there were 200 patients included. Multivariate analyses identified OPNI as an independent prognostic marker that was associated with primary site, tumor size, mitotic index, tumor rupture, necrosis, and modified NIH risk classification. Low OPNI (< 42.6; HR 0.409; P < 0.001) was associated with worse RFS. Conclusions Preoperative OPNI is a novel and useful prognostic marker for GISTs both treated and not treated with TKIs. Higher NLR and PLR have negative effects on RFS. |
topic |
Gastrointestinal stromal tumor Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Onodera’s prognostic nutritional index Propensity score matching Prognostic marker |
url |
https://doi.org/10.1186/s12957-021-02345-9 |
work_keys_str_mv |
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