Familial Occurrence of Adult Granulosa Cell Tumors: Analysis of Whole-Genome Germline Variants

Familial Occurrence of Adult Granulosa Cell Tumors: Analysis of Whole-Genome Germline Variants

Adult granulosa cell tumor (AGCT) is a rare ovarian cancer subtype, with a peak incidence around 50–55 years. Although AGCT can occur in specific syndromes, a genetic predisposition for AGCT has not been identified. The aim of this study is to identify a genetic variant in families with AGCT patient...

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Bibliographic Details
Main Authors: Joline F. Roze, Joachim Kutzera, Wouter Koole, Margreet G. E. M. Ausems, Kristi Engelstad, Jurgen M. J. Piek, Cor D. de Kroon, René H. M. Verheijen, Gijs van Haaften, Ronald P. Zweemer, Glen R. Monroe
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
granulosa cell tumor
sex cord-stromal tumors
ovarian cancer
whole-genome sequencing
<i>FOXL2</i>
Online Access:https://www.mdpi.com/2072-6694/13/10/2430

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