Non-permissive human conventional CD1c+ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization.

Non-permissive human conventional CD1c+ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization.

The BK polyomavirus (BKPyV) is a ubiquitous human virus that persists in the renourinary epithelium. Immunosuppression can lead to BKPyV reactivation in the first year post-transplantation in kidney transplant recipients (KTRs) and hematopoietic stem cell transplant recipients. In KTRs, persistent D...

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Main Authors: Mathieu Sikorski, Flora Coulon, Cécile Peltier, Cécile Braudeau, Alexandra Garcia, Matthieu Giraud, Karine Renaudin, Christine Kandel-Aznar, Steven Nedellec, Philippe Hulin, Julien Branchereau, Joëlle Véziers, Pauline Gaboriaud, Antoine Touzé, Julien Burlaud-Gaillard, Régis Josien, Dorian McIlroy, Céline Bressollette-Bodin, Franck Halary
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009042

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