Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress
Animals cope with changing environments through changes in behavior. Such plasticity is, however, marked by substantial inter-individual variability. Neuroendocrine reactivity to challenging environments can be an important predictor of resilience. Both basolateral amygdala (BLA) neurons and adrenal...
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doaj-7aa4e8acd1404cb7901c31d3e8f6dc7f2020-11-24T22:20:12ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012017-07-0114777910.3390/ijerph14070779ijerph14070779Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to StressAkshaya Hegde0Poh Soh Yee1Rupshi Mitra2School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, SingaporeSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, SingaporeSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, SingaporeAnimals cope with changing environments through changes in behavior. Such plasticity is, however, marked by substantial inter-individual variability. Neuroendocrine reactivity to challenging environments can be an important predictor of resilience. Both basolateral amygdala (BLA) neurons and adrenal glucocorticoid signaling are integral parts of the stress neuroendocrine response. In this report, we test if individual variation in hormonal response to stress is associated with individual variation in the dendritic complexity of BLA neurons. We report a positive correlation between inter-individual variability in glucocorticoid response and neuronal plasticity in the BLA subsequent to a stressor. This suggests that stressful experiences in the past act as significant sculptors of BLA neuronal plasticity and congruent neuroendocrine response.https://www.mdpi.com/1660-4601/14/7/779anxietycorticosteroneinter-individual variationamygdalaneuroendocrinepredator stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akshaya Hegde Poh Soh Yee Rupshi Mitra |
spellingShingle |
Akshaya Hegde Poh Soh Yee Rupshi Mitra Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress International Journal of Environmental Research and Public Health anxiety corticosterone inter-individual variation amygdala neuroendocrine predator stress |
author_facet |
Akshaya Hegde Poh Soh Yee Rupshi Mitra |
author_sort |
Akshaya Hegde |
title |
Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress |
title_short |
Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress |
title_full |
Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress |
title_fullStr |
Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress |
title_full_unstemmed |
Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress |
title_sort |
dendritic architecture of principal basolateral amygdala neurons changes congruently with endocrine response to stress |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2017-07-01 |
description |
Animals cope with changing environments through changes in behavior. Such plasticity is, however, marked by substantial inter-individual variability. Neuroendocrine reactivity to challenging environments can be an important predictor of resilience. Both basolateral amygdala (BLA) neurons and adrenal glucocorticoid signaling are integral parts of the stress neuroendocrine response. In this report, we test if individual variation in hormonal response to stress is associated with individual variation in the dendritic complexity of BLA neurons. We report a positive correlation between inter-individual variability in glucocorticoid response and neuronal plasticity in the BLA subsequent to a stressor. This suggests that stressful experiences in the past act as significant sculptors of BLA neuronal plasticity and congruent neuroendocrine response. |
topic |
anxiety corticosterone inter-individual variation amygdala neuroendocrine predator stress |
url |
https://www.mdpi.com/1660-4601/14/7/779 |
work_keys_str_mv |
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1725776366580793344 |