Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer
Objective: To study the correlation of serum stathmin 1 (STMN1) and cathepsin D (Cath-D) levels with the invasive growth of cervical cancer. Methods: The patients with cervical cancer and those with uterine fibroids who underwent surgical resection in the Second People’s Hospital of Yichang betwe...
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doaj-7aa7fd447a0f4ec286a8c1e82d226c862020-11-25T00:38:35ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-11-0124115760Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancerChun-Lian Zhao0Xiao-Lan Li1Xiao-Xia Chen2Department of Gynecology, the Second People’s Hospital of Yichang Hubei Province, Yichang, Hubei Province, 443000Department of Gynecology, the Second People’s Hospital of Yichang Hubei Province, Yichang, Hubei Province, 443000Department of Gynecology, the Second People’s Hospital of Yichang Hubei Province, Yichang, Hubei Province, 443000Objective: To study the correlation of serum stathmin 1 (STMN1) and cathepsin D (Cath-D) levels with the invasive growth of cervical cancer. Methods: The patients with cervical cancer and those with uterine fibroids who underwent surgical resection in the Second People’s Hospital of Yichang between January 2013 and November 2017 were selected and enrolled in the malignant group and the benign group of the study respectively; the serum was collected before operation to detect the contents of STMN1 and Cath-D; the cervical cancer lesion tissues were collected from the malignant group and the normal cervical tissues were collected from the benign group to measure the expression of STMN1, Cath-D, invasion genes and invasion signal molecules. Results: STMN1 and Cath-D contents in serum as well as STMN1 and Cath-D mRNA expression in lesion tissue of malignant group were significantly higher than those of benign group, and serum STMN1 and Cath-D contents of malignant group were positively correlated with STMN1 and Cath-D mRNA expression in lesion tissue; RACK1, Twist, MMP9, mTOR, S6K1, Wnt and β-catenin mRNA expression in lesion tissue of malignant group were significantly higher than those of benign group whereas E-cadherin, GRIM19 and GSK-3β mRNA expression were significantly lower than those of benign group, and serum STMN1 and Cath-D contents of malignant group were positively correlated with RACK1, Twist, MMP9, mTOR, S6K1, Wnt and β-catenin mRNA expression in lesion tissue, and negatively correlated with E-cadherin, GRIM19 and GSK-3β mRNA expression. Conclusion: The abnormally elevated STMN1 and Cath-D in serum of patients with cervical cancer can evaluate the invasive growth of the lesion.http://www.hnykdxxb.com/PDF/201811/14.pdf Cervical cancerStathmin 1Cathepsin DInvasionSignaling pathway |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chun-Lian Zhao Xiao-Lan Li Xiao-Xia Chen |
spellingShingle |
Chun-Lian Zhao Xiao-Lan Li Xiao-Xia Chen Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer Journal of Hainan Medical University Cervical cancer Stathmin 1 Cathepsin D Invasion Signaling pathway |
author_facet |
Chun-Lian Zhao Xiao-Lan Li Xiao-Xia Chen |
author_sort |
Chun-Lian Zhao |
title |
Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer |
title_short |
Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer |
title_full |
Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer |
title_fullStr |
Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer |
title_full_unstemmed |
Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer |
title_sort |
correlation of serum stmn1 and cath-d levels with the invasive growth of cervical cancer |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2018-11-01 |
description |
Objective: To study the correlation of serum stathmin 1 (STMN1) and cathepsin D (Cath-D)
levels with the invasive growth of cervical cancer. Methods: The patients with cervical cancer
and those with uterine fibroids who underwent surgical resection in the Second People’s
Hospital of Yichang between January 2013 and November 2017 were selected and enrolled in
the malignant group and the benign group of the study respectively; the serum was collected
before operation to detect the contents of STMN1 and Cath-D; the cervical cancer lesion
tissues were collected from the malignant group and the normal cervical tissues were collected
from the benign group to measure the expression of STMN1, Cath-D, invasion genes and
invasion signal molecules. Results: STMN1 and Cath-D contents in serum as well as STMN1
and Cath-D mRNA expression in lesion tissue of malignant group were significantly higher
than those of benign group, and serum STMN1 and Cath-D contents of malignant group were
positively correlated with STMN1 and Cath-D mRNA expression in lesion tissue; RACK1,
Twist, MMP9, mTOR, S6K1, Wnt and β-catenin mRNA expression in lesion tissue of
malignant group were significantly higher than those of benign group whereas E-cadherin,
GRIM19 and GSK-3β mRNA expression were significantly lower than those of benign
group, and serum STMN1 and Cath-D contents of malignant group were positively correlated
with RACK1, Twist, MMP9, mTOR, S6K1, Wnt and β-catenin mRNA expression in lesion
tissue, and negatively correlated with E-cadherin, GRIM19 and GSK-3β mRNA expression.
Conclusion: The abnormally elevated STMN1 and Cath-D in serum of patients with cervical
cancer can evaluate the invasive growth of the lesion. |
topic |
Cervical cancer Stathmin 1 Cathepsin D Invasion Signaling pathway |
url |
http://www.hnykdxxb.com/PDF/201811/14.pdf |
work_keys_str_mv |
AT chunlianzhao correlationofserumstmn1andcathdlevelswiththeinvasivegrowthofcervicalcancer AT xiaolanli correlationofserumstmn1andcathdlevelswiththeinvasivegrowthofcervicalcancer AT xiaoxiachen correlationofserumstmn1andcathdlevelswiththeinvasivegrowthofcervicalcancer |
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1725296725284880384 |