Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction

Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction

Cytoplasmic dynein plays critical roles within the developing and mature nervous systems, including effecting nuclear migration, and retrograde transport of various cargos. Unsurprisingly, mutations in dynein are causative of various developmental neuropathies and motor neuron diseases. These ‘dynei...

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Bibliographic Details
Main Authors: Matthew G Marzo, Jacqueline M Griswold, Kristina M Ruff, Rachel E Buchmeier, Colby P Fees, Steven M Markus
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
dynein
neurological disease
spindle positioning
dyneinopathy
muscular dystrophy
malformations of cortical development
Online Access:https://elifesciences.org/articles/47246

Internet

https://elifesciences.org/articles/47246

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