A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation
Jingde Chen,* Hong Jiang,* Yin Wu, Yandong Li, Yong GaoDepartment of Oncology and Hematology, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workAbstract: In this study, oxaliplatin (OX) liposomes...
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doaj-7aaebafbb9714542a5fd0811b384229f2020-11-24T22:35:13ZengDove Medical PressDrug Design, Development and Therapy1177-88812015-04-012015default2265227521415A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluationChen JJiang HWu YLi YGao YJingde Chen,* Hong Jiang,* Yin Wu, Yandong Li, Yong GaoDepartment of Oncology and Hematology, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workAbstract: In this study, oxaliplatin (OX) liposomes surface-modified with glycyrrhetinic acid (GA) were developed by the film-dispersion method. Their morphology, physical and chemical properties, and in vitro release performance were investigated. The transmission electron microscope (TEM) image showed that most liposomes were spherical particles with similar size and uniform dispersion. Both OX-liposomes and GA-OX-liposomes had an average size of 90 nm. They were negatively charged, with zeta potentials of -20.6 and -21.3 mV, respectively, and the entrapment efficiency values of both were higher than 94%. In vitro data showed that the application of liposomes could prolong the OX release. The relatively high correlation coefficient values obtained from analyzing the amount of drug released versus the square root of time depicted that release followed the Weibull model. No significant changes were observed after the addition of GA to the liposomes. In vivo, the relatively long time to reach the maximum plasma concentration of OX-liposomes suggested a sustained-release profile of liposomes, which was consistent with the results of the in vitro release study. The increased area under the curve and maximum plasma concentration of OX-liposomes and GA-OX-liposomes demonstrated an increased absorption. The drug concentration in tissues indicated that the GA-modified liposomes delivered OX mainly to liver after intravenous administration. In addition, no severe signs, such as appearance of epithelial necrosis or sloughing of epithelial cells, were detected in histology studies.Keywords: target, drug delivery, modified liposomes, pharmacokinetics, biodistributionhttp://www.dovepress.com/a-novel-glycyrrhetinic-acid-modified-oxaliplatin-liposome-for-liver-ta-peer-reviewed-article-DDDT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chen J Jiang H Wu Y Li Y Gao Y |
spellingShingle |
Chen J Jiang H Wu Y Li Y Gao Y A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation Drug Design, Development and Therapy |
author_facet |
Chen J Jiang H Wu Y Li Y Gao Y |
author_sort |
Chen J |
title |
A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation |
title_short |
A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation |
title_full |
A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation |
title_fullStr |
A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation |
title_full_unstemmed |
A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation |
title_sort |
novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation |
publisher |
Dove Medical Press |
series |
Drug Design, Development and Therapy |
issn |
1177-8881 |
publishDate |
2015-04-01 |
description |
Jingde Chen,* Hong Jiang,* Yin Wu, Yandong Li, Yong GaoDepartment of Oncology and Hematology, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workAbstract: In this study, oxaliplatin (OX) liposomes surface-modified with glycyrrhetinic acid (GA) were developed by the film-dispersion method. Their morphology, physical and chemical properties, and in vitro release performance were investigated. The transmission electron microscope (TEM) image showed that most liposomes were spherical particles with similar size and uniform dispersion. Both OX-liposomes and GA-OX-liposomes had an average size of 90 nm. They were negatively charged, with zeta potentials of -20.6 and -21.3 mV, respectively, and the entrapment efficiency values of both were higher than 94%. In vitro data showed that the application of liposomes could prolong the OX release. The relatively high correlation coefficient values obtained from analyzing the amount of drug released versus the square root of time depicted that release followed the Weibull model. No significant changes were observed after the addition of GA to the liposomes. In vivo, the relatively long time to reach the maximum plasma concentration of OX-liposomes suggested a sustained-release profile of liposomes, which was consistent with the results of the in vitro release study. The increased area under the curve and maximum plasma concentration of OX-liposomes and GA-OX-liposomes demonstrated an increased absorption. The drug concentration in tissues indicated that the GA-modified liposomes delivered OX mainly to liver after intravenous administration. In addition, no severe signs, such as appearance of epithelial necrosis or sloughing of epithelial cells, were detected in histology studies.Keywords: target, drug delivery, modified liposomes, pharmacokinetics, biodistribution |
url |
http://www.dovepress.com/a-novel-glycyrrhetinic-acid-modified-oxaliplatin-liposome-for-liver-ta-peer-reviewed-article-DDDT |
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