Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation
The human thyroid gland acquires a differentiation program as early as weeks 3–4 of embryonic development. The onset of functional differentiation, which manifests by the appearance of colloid in thyroid follicles, takes place during gestation weeks 10–11. By 12–13 weeks functional differentiation i...
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doaj-7aaf871f0a46472385a05289cb05ae672021-06-11T09:39:45ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-06-01910.3389/fcell.2021.669354669354Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional MaturationGeneviève Dom0Geneviève Dom1Petr Dmitriev2Petr Dmitriev3Marie-Alexandra Lambot4Guy Van Vliet5Guy Van Vliet6Daniel Glinoer7Frédérick Libert8Anne Lefort9Jacques E. Dumont10Jacques E. Dumont11Carine Maenhaut12Carine Maenhaut13School of Medicine, IRIBHM, Université libre de Bruxelles, Brussels, BelgiumInstitute of Interdisciplinary Research in Human and Molecular Biology, Brussels, BelgiumSchool of Medicine, IRIBHM, Université libre de Bruxelles, Brussels, BelgiumInstitute of Interdisciplinary Research in Human and Molecular Biology, Brussels, BelgiumHôpital Saint-Pierre, Université libre de Bruxelles, Brussels, BelgiumDépartement de Pédiatrie, Université de Montréal, Montreal, QC, CanadaCHU Sainte-Justine, Montreal, QC, CanadaHôpital Saint-Pierre, Université libre de Bruxelles, Brussels, BelgiumIRIDIA, Université libre de Bruxelles, Brussels, BelgiumSchool of Medicine, IRIBHM, Université libre de Bruxelles, Brussels, BelgiumSchool of Medicine, IRIBHM, Université libre de Bruxelles, Brussels, BelgiumInstitute of Interdisciplinary Research in Human and Molecular Biology, Brussels, BelgiumSchool of Medicine, IRIBHM, Université libre de Bruxelles, Brussels, BelgiumInstitute of Interdisciplinary Research in Human and Molecular Biology, Brussels, BelgiumThe human thyroid gland acquires a differentiation program as early as weeks 3–4 of embryonic development. The onset of functional differentiation, which manifests by the appearance of colloid in thyroid follicles, takes place during gestation weeks 10–11. By 12–13 weeks functional differentiation is accomplished and the thyroid is capable of producing thyroid hormones although at a low level. During maturation, thyroid hormones yield increases and physiological mechanisms of thyroid hormone synthesis regulation are established. In the present work we traced the process of thyroid functional differentiation and maturation in the course of human development by performing transcriptomic analysis of human thyroids covering the period of gestation weeks 7–11 and comparing it to adult human thyroid. We obtained specific transcriptomic signatures of embryonic and adult human thyroids by comparing them to non-thyroid tissues from human embryos and adults. We defined a non-TSH (thyroid stimulating hormone) dependent transition from differentiation to maturation of thyroid. The study also sought to shed light on possible factors that could replace TSH, which is absent in this window of gestational age, to trigger transition to the emergence of thyroid function. We propose a list of possible genes that may also be involved in abnormalities in thyroid differentiation and/or maturation, hence leading to congenital hypothyroidism. To our knowledge, this study represent the first transcriptomic analysis of human embryonic thyroid and its comparison to adult thyroid.https://www.frontiersin.org/articles/10.3389/fcell.2021.669354/fullfetal thyroidthyroid function maturationTSHFGFIGF1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Geneviève Dom Geneviève Dom Petr Dmitriev Petr Dmitriev Marie-Alexandra Lambot Guy Van Vliet Guy Van Vliet Daniel Glinoer Frédérick Libert Anne Lefort Jacques E. Dumont Jacques E. Dumont Carine Maenhaut Carine Maenhaut |
spellingShingle |
Geneviève Dom Geneviève Dom Petr Dmitriev Petr Dmitriev Marie-Alexandra Lambot Guy Van Vliet Guy Van Vliet Daniel Glinoer Frédérick Libert Anne Lefort Jacques E. Dumont Jacques E. Dumont Carine Maenhaut Carine Maenhaut Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation Frontiers in Cell and Developmental Biology fetal thyroid thyroid function maturation TSH FGF IGF1 |
author_facet |
Geneviève Dom Geneviève Dom Petr Dmitriev Petr Dmitriev Marie-Alexandra Lambot Guy Van Vliet Guy Van Vliet Daniel Glinoer Frédérick Libert Anne Lefort Jacques E. Dumont Jacques E. Dumont Carine Maenhaut Carine Maenhaut |
author_sort |
Geneviève Dom |
title |
Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation |
title_short |
Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation |
title_full |
Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation |
title_fullStr |
Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation |
title_full_unstemmed |
Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation |
title_sort |
transcriptomic signature of human embryonic thyroid reveals transition from differentiation to functional maturation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-06-01 |
description |
The human thyroid gland acquires a differentiation program as early as weeks 3–4 of embryonic development. The onset of functional differentiation, which manifests by the appearance of colloid in thyroid follicles, takes place during gestation weeks 10–11. By 12–13 weeks functional differentiation is accomplished and the thyroid is capable of producing thyroid hormones although at a low level. During maturation, thyroid hormones yield increases and physiological mechanisms of thyroid hormone synthesis regulation are established. In the present work we traced the process of thyroid functional differentiation and maturation in the course of human development by performing transcriptomic analysis of human thyroids covering the period of gestation weeks 7–11 and comparing it to adult human thyroid. We obtained specific transcriptomic signatures of embryonic and adult human thyroids by comparing them to non-thyroid tissues from human embryos and adults. We defined a non-TSH (thyroid stimulating hormone) dependent transition from differentiation to maturation of thyroid. The study also sought to shed light on possible factors that could replace TSH, which is absent in this window of gestational age, to trigger transition to the emergence of thyroid function. We propose a list of possible genes that may also be involved in abnormalities in thyroid differentiation and/or maturation, hence leading to congenital hypothyroidism. To our knowledge, this study represent the first transcriptomic analysis of human embryonic thyroid and its comparison to adult thyroid. |
topic |
fetal thyroid thyroid function maturation TSH FGF IGF1 |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.669354/full |
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