Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea

Pinocembrin ameliorates intermittent hypoxia-induced neuroinflammation through BNIP3-dependent mitophagy in a murine model of sleep apnea

Abstract Background Intermittent hypoxia (IH) caused by obstructive sleep apnea (OSA) leads to neuroinflammation. Pinocembrin has been shown to have neuroprotective effects, while the therapeutic functions under IH condition are still unknown. Methods An OSA model was established by CIH exposure ins...

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Bibliographic Details
Main Authors: Lin-Jing Gong, Xin-Yuan Wang, Wen-Yu Gu, Xu Wu
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Neuroinflammation
Subjects:
Pinocembrin
Neuroinflammation
Microglia
Obstructive sleep apnea (OSA)
BNIP3
Mitophagy
Online Access:http://link.springer.com/article/10.1186/s12974-020-02014-w

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http://link.springer.com/article/10.1186/s12974-020-02014-w

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