Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining.
For more than half a century, genotoxic agents have been used to induce mutations in the genome of model organisms to establish genotype-phenotype relationships. While inaccurate replication across damaged bases can explain the formation of single nucleotide variants, it remained unknown how DNA dam...
Main Authors: | Robin van Schendel, Jane van Heteren, Richard Welten, Marcel Tijsterman |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-10-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5068794?pdf=render |
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