Tau structures

Tau structures

Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary and quaternary tau structures. We describe the structure of tau from its specific residues until its...

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Main Authors: Jesus Avila, Juan S. Jimenez, Carmen Laura Sayas, Marta Bolós, Juan C. Zabala, Germán Rivas, Felix Hernandez
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Microtubule-Associated Proteins
Aggregation
posttranslational modification
motifs
PHFs
Tubulin binding
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00262/full
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spelling doaj-7abc40594b4446d0a5b751d9b54ad8072020-11-24T23:48:55ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-11-01810.3389/fnagi.2016.00262224100Tau structuresJesus Avila0Jesus Avila1Juan S. Jimenez2Carmen Laura Sayas3Marta Bolós4Marta Bolós5Juan C. Zabala6Germán Rivas7Felix Hernandez8Felix Hernandez9Centro de Biología Molecular Severo Ochoa CSIC­UAMCIBERNEDUniversidad Autonoma de MadridUniversity of La LagunaCentro de Biología Molecular Severo Ochoa CSIC­UAMCIBERNEDIFIMAV-Universidad de CantabriaCentro de Investigaciones Biologicas (CIB), CSICCentro de Biología Molecular Severo Ochoa CSIC­UAMCIBERNEDTau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers and larger polymers in physiological and pathological situations.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00262/fullMicrotubule-Associated ProteinsAggregationposttranslational modificationmotifsPHFsTubulin binding
collection DOAJ
language English
format Article
sources DOAJ
author Jesus Avila
Jesus Avila
Juan S. Jimenez
Carmen Laura Sayas
Marta Bolós
Marta Bolós
Juan C. Zabala
Germán Rivas
Felix Hernandez
Felix Hernandez
spellingShingle Jesus Avila
Jesus Avila
Juan S. Jimenez
Carmen Laura Sayas
Marta Bolós
Marta Bolós
Juan C. Zabala
Germán Rivas
Felix Hernandez
Felix Hernandez
Tau structures
Frontiers in Aging Neuroscience
Microtubule-Associated Proteins
Aggregation
posttranslational modification
motifs
PHFs
Tubulin binding
author_facet Jesus Avila
Jesus Avila
Juan S. Jimenez
Carmen Laura Sayas
Marta Bolós
Marta Bolós
Juan C. Zabala
Germán Rivas
Felix Hernandez
Felix Hernandez
author_sort Jesus Avila
title Tau structures
title_short Tau structures
title_full Tau structures
title_fullStr Tau structures
title_full_unstemmed Tau structures
title_sort tau structures
publisher Frontiers Media S.A.
series Frontiers in Aging Neuroscience
issn 1663-4365
publishDate 2016-11-01
description Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers and larger polymers in physiological and pathological situations.
topic Microtubule-Associated Proteins
Aggregation
posttranslational modification
motifs
PHFs
Tubulin binding
url http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00262/full
work_keys_str_mv AT jesusavila taustructures
AT jesusavila taustructures
AT juansjimenez taustructures
AT carmenlaurasayas taustructures
AT martabolos taustructures
AT martabolos taustructures
AT juanczabala taustructures
AT germanrivas taustructures
AT felixhernandez taustructures
AT felixhernandez taustructures
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