NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer
Abstract Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients their role is still controversial and no data about the possible correlation with the BRCA-status has been ever re...
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doaj-7ac325423fbd40e8b6a886986321c46c2021-05-30T11:38:51ZengNature Publishing GroupScientific Reports2045-23222021-05-011111810.1038/s41598-021-90361-wNLR and BRCA mutational status in patients with high grade serous advanced ovarian cancerClaudia Marchetti0Marco D’Indinosante1Carolina Bottoni2Chiara Di Ilio3Stefano Di Berardino4Barbara Costantini5Angelo Minucci6Laura Vertechy7Giovanni Scambia8Anna Fagotti9Department of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSMolecular and Genomic Diagnostics Laboratory, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSDepartment of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCSAbstract Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients their role is still controversial and no data about the possible correlation with the BRCA-status has been ever reported. We consecutively enrolled a series of 397 newly diagnosed high-grade serous-advanced OC-patients. All patients were tested for BRCA-mutational-status and blood-parameters have been collected 48 h before staging-surgery. A significant correlation of NLR with disease distribution (p < 0.005) was found and patients with NLR < 4 underwent primary-debulking-surgery more frequently (p-value 0.001), with a lower surgical-complexity-score (p-value 0.002). Regarding survival-data, patients with NLR < 4 had a significant 7-month increase in mPFS (26 vs 19 months, p = 0.009); focusing on the BRCA-status, among both BRCA-mutated and BRCA-wild type patients, those with lower NLR had a significantly prolonged mPFS compared to patients with NLR > 4 (BRCA-mutated: 35 vs 23 months, p = 0.03; BRCA-wt: 19 vs 16 months, p = 0.05). At multivariate-analysis, independent factors of prolonged PFS were BRCA mutational status, having received complete cytoreduction and NLR < 4. Also, the strongest predictors of longer OS were BRCA-mutational status, having received complete cytoreductive surgery, NLR < 4 and age. NLR is confirmed to be a prognostic marker in OC-patients and it seems unrelated with BRCA-mutational status.https://doi.org/10.1038/s41598-021-90361-w |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudia Marchetti Marco D’Indinosante Carolina Bottoni Chiara Di Ilio Stefano Di Berardino Barbara Costantini Angelo Minucci Laura Vertechy Giovanni Scambia Anna Fagotti |
spellingShingle |
Claudia Marchetti Marco D’Indinosante Carolina Bottoni Chiara Di Ilio Stefano Di Berardino Barbara Costantini Angelo Minucci Laura Vertechy Giovanni Scambia Anna Fagotti NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer Scientific Reports |
author_facet |
Claudia Marchetti Marco D’Indinosante Carolina Bottoni Chiara Di Ilio Stefano Di Berardino Barbara Costantini Angelo Minucci Laura Vertechy Giovanni Scambia Anna Fagotti |
author_sort |
Claudia Marchetti |
title |
NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer |
title_short |
NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer |
title_full |
NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer |
title_fullStr |
NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer |
title_full_unstemmed |
NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer |
title_sort |
nlr and brca mutational status in patients with high grade serous advanced ovarian cancer |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-05-01 |
description |
Abstract Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients their role is still controversial and no data about the possible correlation with the BRCA-status has been ever reported. We consecutively enrolled a series of 397 newly diagnosed high-grade serous-advanced OC-patients. All patients were tested for BRCA-mutational-status and blood-parameters have been collected 48 h before staging-surgery. A significant correlation of NLR with disease distribution (p < 0.005) was found and patients with NLR < 4 underwent primary-debulking-surgery more frequently (p-value 0.001), with a lower surgical-complexity-score (p-value 0.002). Regarding survival-data, patients with NLR < 4 had a significant 7-month increase in mPFS (26 vs 19 months, p = 0.009); focusing on the BRCA-status, among both BRCA-mutated and BRCA-wild type patients, those with lower NLR had a significantly prolonged mPFS compared to patients with NLR > 4 (BRCA-mutated: 35 vs 23 months, p = 0.03; BRCA-wt: 19 vs 16 months, p = 0.05). At multivariate-analysis, independent factors of prolonged PFS were BRCA mutational status, having received complete cytoreduction and NLR < 4. Also, the strongest predictors of longer OS were BRCA-mutational status, having received complete cytoreductive surgery, NLR < 4 and age. NLR is confirmed to be a prognostic marker in OC-patients and it seems unrelated with BRCA-mutational status. |
url |
https://doi.org/10.1038/s41598-021-90361-w |
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