Neutrophils and Immunity: From Bactericidal Action to Being Conquered
The neutrophil is the major phagocyte and the final effector cell of the innate immunity, with a primary role in the clearance of extracellular pathogens. Using the broad array of cytokines, extracellular traps, and effector molecules as the humoral arm, neutrophils play a crucial role in the host d...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2017-01-01
|
Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2017/9671604 |
id |
doaj-7ac62abc291542399a74fd689633c908 |
---|---|
record_format |
Article |
spelling |
doaj-7ac62abc291542399a74fd689633c9082020-11-24T22:25:59ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/96716049671604Neutrophils and Immunity: From Bactericidal Action to Being ConqueredTie-Shan Teng0Ai-ling Ji1Xin-Ying Ji2Yan-Zhang Li3School of Medical Sciences, College of Medicine, Henan University, Kaifeng, Henan 475004, ChinaSchool of Medical Sciences, College of Medicine, Henan University, Kaifeng, Henan 475004, ChinaSchool of Medical Sciences, College of Medicine, Henan University, Kaifeng, Henan 475004, ChinaSchool of Medical Sciences, College of Medicine, Henan University, Kaifeng, Henan 475004, ChinaThe neutrophil is the major phagocyte and the final effector cell of the innate immunity, with a primary role in the clearance of extracellular pathogens. Using the broad array of cytokines, extracellular traps, and effector molecules as the humoral arm, neutrophils play a crucial role in the host defense against pathogen infections. On the other hand, the pathogen has the capacity to overcome neutrophil-mediated host defense to establish infection causing human disease. Pathogens, such as S. aureus, have the potential to thwart neutrophil chemotaxis and phagocytosis and thereby succeed in evading killing by neutrophils. Furthermore, S. aureus surviving within neutrophils promotes neutrophil cytolysis, resulting in the release of host-derived molecules that promote local inflammation. Here, we provide a detailed overview of the mechanisms by which neutrophils kill the extracellular pathogens and how pathogens evade neutrophils degradation. This review will provide insights that might be useful for the development of novel therapies against infections caused by antibiotic resistant pathogens.http://dx.doi.org/10.1155/2017/9671604 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tie-Shan Teng Ai-ling Ji Xin-Ying Ji Yan-Zhang Li |
spellingShingle |
Tie-Shan Teng Ai-ling Ji Xin-Ying Ji Yan-Zhang Li Neutrophils and Immunity: From Bactericidal Action to Being Conquered Journal of Immunology Research |
author_facet |
Tie-Shan Teng Ai-ling Ji Xin-Ying Ji Yan-Zhang Li |
author_sort |
Tie-Shan Teng |
title |
Neutrophils and Immunity: From Bactericidal Action to Being Conquered |
title_short |
Neutrophils and Immunity: From Bactericidal Action to Being Conquered |
title_full |
Neutrophils and Immunity: From Bactericidal Action to Being Conquered |
title_fullStr |
Neutrophils and Immunity: From Bactericidal Action to Being Conquered |
title_full_unstemmed |
Neutrophils and Immunity: From Bactericidal Action to Being Conquered |
title_sort |
neutrophils and immunity: from bactericidal action to being conquered |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2017-01-01 |
description |
The neutrophil is the major phagocyte and the final effector cell of the innate immunity, with a primary role in the clearance of extracellular pathogens. Using the broad array of cytokines, extracellular traps, and effector molecules as the humoral arm, neutrophils play a crucial role in the host defense against pathogen infections. On the other hand, the pathogen has the capacity to overcome neutrophil-mediated host defense to establish infection causing human disease. Pathogens, such as S. aureus, have the potential to thwart neutrophil chemotaxis and phagocytosis and thereby succeed in evading killing by neutrophils. Furthermore, S. aureus surviving within neutrophils promotes neutrophil cytolysis, resulting in the release of host-derived molecules that promote local inflammation. Here, we provide a detailed overview of the mechanisms by which neutrophils kill the extracellular pathogens and how pathogens evade neutrophils degradation. This review will provide insights that might be useful for the development of novel therapies against infections caused by antibiotic resistant pathogens. |
url |
http://dx.doi.org/10.1155/2017/9671604 |
work_keys_str_mv |
AT tieshanteng neutrophilsandimmunityfrombactericidalactiontobeingconquered AT ailingji neutrophilsandimmunityfrombactericidalactiontobeingconquered AT xinyingji neutrophilsandimmunityfrombactericidalactiontobeingconquered AT yanzhangli neutrophilsandimmunityfrombactericidalactiontobeingconquered |
_version_ |
1725755246104281088 |